Structured evidence table for Black Seed Anxiety Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Seed Anxiety Randomized Trial | The clinical impact is meaningful, as bloating and gas-related symptoms are associated with reduced quality-of-life and higher levels of stress and anxiety []. | 2 | Allegretti Jessica R. (2026) | A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort |
| Black Seed Anxiety Randomized Trial | Clinically, disruption of GI barrier function is linked to increased sensitivity to visceral and somatic stimuli []. | 2 | Allegretti Jessica R. (2026) | A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort |
| Black Seed Anxiety Randomized Trial | A trial of a single-strain probiotic (35624) over 4 weeks found no improvement in bloating or abdominal discomfort compared with placebo []. | 2 | Allegretti Jessica R. (2026) | A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort |
| Black Seed Anxiety Randomized Trial | 1 2 2 3 3 Bloating and abdominal discomfort represent common clinical concerns in the general population. | 2 | Allegretti Jessica R. (2026) | A Randomized, Placebo-Controlled Trial Evaluating Multi-Species Synbiotic Supplementation for Bloating, Gas, and Abdominal Discomfort |
| Black Seed Anxiety Randomized Trial | Severity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Anxiety Randomized Trial | Conclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Anxiety Randomized Trial | Background The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
| Black Seed Anxiety Randomized Trial | Materials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks. | 2 | Eshaghian N (2025) | Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. |
Source documents