Structured evidence table for Black Garlic Cardiometabolic Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Black Garlic Cardiometabolic Meta-Analysis | 1 2 3 Metabolic Syndrome (MetS) is a cluster of metabolic disorders, including, among others, insulin resistance, dyslipidemia, and hypertension, that significantly increase the risk of developing type II diabetes (T2DM) and cardiovascular disease (CVDs) [,]. | 3 | Geddo Federica (2025) | Tracing the Path from Obesity to Diabetes: How S-Allyl Cysteine Shapes Metabolic Health |
| Black Garlic Cardiometabolic Meta-Analysis | Furthermore, the work examines the origin of SAC from garlic maturation, safety, and bioavailability, and the current evidence on its protective effects on several clinical outcomes associated with MetS. | 3 | Geddo Federica (2025) | Tracing the Path from Obesity to Diabetes: How S-Allyl Cysteine Shapes Metabolic Health |
| Black Garlic Cardiometabolic Meta-Analysis | It is clinically associated not only with an increased risk of developing T2DM, but also with accelerated atherosclerosis driven by chronic inflammation and vascular endothelial dysfunction, conferring a significantly increased cardiovascular risk []. | 3 | Geddo Federica (2025) | Tracing the Path from Obesity to Diabetes: How S-Allyl Cysteine Shapes Metabolic Health |
| Black Garlic Cardiometabolic Meta-Analysis | The first step in the management of MetS is lifestyle modification, with the adoption of a healthy diet and regular physical activity. | 3 | Geddo Federica (2025) | Tracing the Path from Obesity to Diabetes: How S-Allyl Cysteine Shapes Metabolic Health |
| Black Garlic Cardiometabolic Meta-Analysis | Dysregulation of this axis contributes to hypercholesterolemia and cardiometabolic risk, beyond classical cholesterol synthesis pathways. | 4 | Uberti F (2026) | Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro. |
| Black Garlic Cardiometabolic Meta-Analysis | In HepG2 cells, MIX demonstrated synergistic effects: it reduced HMGR expression by 83-90% relative to individual extracts, increased LDLR expression by 43-97%, suppressed PCSK9 by up to 92%, and lowered total cholesterol and LDL uptake more effectively than RYRF. | 4 | Uberti F (2026) | Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro. |
| Black Garlic Cardiometabolic Meta-Analysis | MIX also amplified bile acid production and free cholesterol excretion, indicating improved hepatic clearance pathways. | 4 | Uberti F (2026) | Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro. |
| Black Garlic Cardiometabolic Meta-Analysis | Background/Objectives: The gut-liver axis plays a central role in cholesterol homeostasis, linking intestinal absorption, microbial metabolites, and hepatic lipid regulation. | 4 | Uberti F (2026) | Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro. |
Source documents