topicBilberry Blood Glucose Randomized Trial
claimAlthough the exact mechanisms underlying MetS pathophysiology are still not fully elucidated, it is well established that the condition is accompanied by increased oxidative stress and inflammation.
evidence level3
citationVidovic Nevena (2025)
sourcePolyphenol-Rich Beverages Exert Beneficial but Variable Effects on Oxidative, and Inflammatory Markers in Metabolic Syndrome and Related Conditions: Evidence of Human Trials
topicBilberry Blood Glucose Randomized Trial
claimIncreased adiposity, closely related to metabolic syndrome, promotes inflammation and oxidative stress, both of which contribute to the development of MetS components, including insulin resistance, dyslipidemia, and hypertension [].
evidence level3
citationVidovic Nevena (2025)
sourcePolyphenol-Rich Beverages Exert Beneficial but Variable Effects on Oxidative, and Inflammatory Markers in Metabolic Syndrome and Related Conditions: Evidence of Human Trials
topicBilberry Blood Glucose Randomized Trial
claim7 5 Besides oxidative stress, MetS has been linked to increased inflammatory burden.
evidence level3
citationVidovic Nevena (2025)
sourcePolyphenol-Rich Beverages Exert Beneficial but Variable Effects on Oxidative, and Inflammatory Markers in Metabolic Syndrome and Related Conditions: Evidence of Human Trials
topicBilberry Blood Glucose Randomized Trial
claim1 2 1 3 Metabolic syndrome (MetS), also known as “Syndrome X” and “Insulin Resistance Syndrome”, represents one of the major global public health concerns, as its prevalence keeps increasing [].
evidence level3
citationVidovic Nevena (2025)
sourcePolyphenol-Rich Beverages Exert Beneficial but Variable Effects on Oxidative, and Inflammatory Markers in Metabolic Syndrome and Related Conditions: Evidence of Human Trials
topicBilberry Blood Glucose Randomized Trial
claimIn addition to having a detrimental impact on everyday activities and quality of life, impaired vision also raises the likelihood of depression and disability in later life and can result in a loss of independence [,].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBilberry Blood Glucose Randomized Trial
claimIncreasing evidence suggests that diet and specific nutrients may modulate these interconnected molecular networks, complementing standard pharmacological or surgical treatments and potentially slowing disease progression [,,].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBilberry Blood Glucose Randomized Trial
claimFor example, key endogenous antioxidant pathways such as the Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling system, responsible for the transcription of protective enzymes like heme oxygenase-1 (HO-1), glutathione peroxidase, and superoxide dismutase (SOD), are often impaired in ocular pathology [].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases
topicBilberry Blood Glucose Randomized Trial
claim1 2 3 4 Nowadays, one of the goals of the United Nations Summit on Sustainable Development is to improve eye health, which may be accomplished by including measures for care, prevention, promotion, and rehabilitation [].
evidence level4
citationD’Angelo Angela (2025)
sourcePolyphenols and Eye Health: A Narrative Review of the Literature on the Therapeutic Effects for Ocular Diseases