Structured evidence table for Betaine Muscle Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Betaine Muscle Performance Randomized Trial | Interventions that alter metabolite availability or metabolism, such as caloric restriction (CR) or reduced insulin/IGF‐1 signaling (IIS), extend lifespan across species (Gao et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Muscle Performance Randomized Trial | This review highlights the role of endogenous metabolites in regulating longevity pathways and evaluates evidence across species to aid understanding metabolic regulation of aging and guiding future investigations. | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Muscle Performance Randomized Trial | In UVB‐irradiated hairless mice, oral taurine preserved epidermal moisture and significantly reduced wrinkle formation, suggesting an anti‐photoaging action via its osmolyte and moisturizing roles (Yoshimura et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Muscle Performance Randomized Trial | 2023 2018 2021 2025 2013 Aging is a multifactorial process driven by the interplay of genetic, environmental, and metabolic perturbations, with dysregulated nutrient sensing and metabolic dysfunction recognized as core hallmarks (Lopez‐Otin et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Muscle Performance Randomized Trial | No trial differences were found for I-FABP (interaction effect, p = 0.076), L: 13 CM ( p = 0.559), the neutrophil/lymphocyte ratio ( p = 0.171), serum cortisol ( p = 0.982), serum myoglobin ( p = 0.942), or serum creatine kinase ( p = 0.694). | 4 | Nieman DC (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. |
| Betaine Muscle Performance Randomized Trial | Conclusions Betaine supplementation modestly improved 60 km cycling performance but had no effect on gut permeability. | 4 | Nieman DC (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. |
| Betaine Muscle Performance Randomized Trial | Background/objectives This study examined the effects of 2 weeks of betaine versus placebo supplementation (3 g/d) on 60 km cycling performance, gut permeability, and shifts in plasma metabolites. | 4 | Nieman DC (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. |
| Betaine Muscle Performance Randomized Trial | A randomized, placebo-controlled, double-blind, crossover design was used with two 2-week supplementation periods and a 2-week washout period. | 4 | Nieman DC (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery. |
Source documents