Structured evidence table for Betaine Exercise Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Betaine Exercise Performance Randomized Trial | Interventions that alter metabolite availability or metabolism, such as caloric restriction (CR) or reduced insulin/IGF‐1 signaling (IIS), extend lifespan across species (Gao et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Exercise Performance Randomized Trial | This review highlights the role of endogenous metabolites in regulating longevity pathways and evaluates evidence across species to aid understanding metabolic regulation of aging and guiding future investigations. | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Exercise Performance Randomized Trial | In UVB‐irradiated hairless mice, oral taurine preserved epidermal moisture and significantly reduced wrinkle formation, suggesting an anti‐photoaging action via its osmolyte and moisturizing roles (Yoshimura et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Exercise Performance Randomized Trial | 2023 2018 2021 2025 2013 Aging is a multifactorial process driven by the interplay of genetic, environmental, and metabolic perturbations, with dysregulated nutrient sensing and metabolic dysfunction recognized as core hallmarks (Lopez‐Otin et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Exercise Performance Randomized Trial | Plasma betaine concentrations are inversely associated with cardiovascular events [], and higher levels have been linked to a pattern of favorable lifestyle habits and leanness []. | 4 | Nieman David C. (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery |
| Betaine Exercise Performance Randomized Trial | The ergogenic and clinical effects of betaine have been investigated with doses ranging from 0.5 to 20 g/d, with 1.5–6 g/d found to be sufficient to increase plasma betaine and methionine concentrations and lower homocysteine within 2 weeks []. | 4 | Nieman David C. (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery |
| Betaine Exercise Performance Randomized Trial | No sex differences were found for 60 km cycling performance in terms of average percent maximal heart rate, power output in watts, and oxygen consumption rates (all> 0.13). | 4 | Nieman David C. (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery |
| Betaine Exercise Performance Randomized Trial | 1 2 3 4 5 Prolonged and intensive endurance exercise causes post-exercise inflammation, oxidative stress, immune suppression, and extensive perturbations in hundreds of circulating proteins and metabolites. | 4 | Nieman David C. (2025) | Betaine Supplementation Improves 60 km Cycling Time Trial Performance and One-Carbon Metabolism in Cyclists During Recovery |
Source documents