Structured evidence table for Betaine Cognition Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Betaine Cognition Randomized Trial | Interventions that alter metabolite availability or metabolism, such as caloric restriction (CR) or reduced insulin/IGF‐1 signaling (IIS), extend lifespan across species (Gao et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Cognition Randomized Trial | This review highlights the role of endogenous metabolites in regulating longevity pathways and evaluates evidence across species to aid understanding metabolic regulation of aging and guiding future investigations. | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Cognition Randomized Trial | In UVB‐irradiated hairless mice, oral taurine preserved epidermal moisture and significantly reduced wrinkle formation, suggesting an anti‐photoaging action via its osmolyte and moisturizing roles (Yoshimura et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Cognition Randomized Trial | 2023 2018 2021 2025 2013 Aging is a multifactorial process driven by the interplay of genetic, environmental, and metabolic perturbations, with dysregulated nutrient sensing and metabolic dysfunction recognized as core hallmarks (Lopez‐Otin et al. ). | 3 | Jiang Yizhou (2026) | Lifespan‐Extending Endogenous Metabolites |
| Betaine Cognition Randomized Trial | With the global population aging, the prevalence of impairment and neurocognitive disorders has increased substantially, intensifying public health concerns [,]. | 4 | Hardaway Chante (2026) | Brain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course |
| Betaine Cognition Randomized Trial | Among these, nutrition has emerged as a central and potentially scalable factor, with converging evidence suggesting that dietary exposures meaningfully influence brain structure [], function [], and long-term cognitive trajectories []. | 4 | Hardaway Chante (2026) | Brain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course |
| Betaine Cognition Randomized Trial | Consequently, diets rich in berries, nuts, whole grains, leafy green vegetables, and fatty fish have been frequently characterized as “brain-supportive” due to their bioactive profiles and associations with improved cognitive outcomes []. | 4 | Hardaway Chante (2026) | Brain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course |
| Betaine Cognition Randomized Trial | 1 2 3 4 5 6 7 Cognitive function underpins virtually all domains of daily life, influencing learning, memory, executing functioning, problem-solving, and adaptive behavior []. | 4 | Hardaway Chante (2026) | Brain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course |
Source documents