topicBeta-Sitosterol Cholesterol Randomized Trial
claimAn improvement in the lipid profile, particularly a reduction in low-density lipoprotein cholesterol (LDL-C), is desirable owing to the causal relationship between increased LDL-C and the risk of ASCVD.
evidence level2
citationJohnen Jana (2026)
sourceEffects of regular consumption of a β-glucan-rich oyster mushroom powder on cholesterol metabolism in adults with moderately elevated LDL-cholesterol concentrations: a double-blind randomized controlled trial
topicBeta-Sitosterol Cholesterol Randomized Trial
claimThis effect has been attributed to the increased viscosity of the chyme, formation of a gel on the intestinal mucosal surface, and binding of bile acids, which consequently lowers the re-/absorption of cholesterol and bile acids.
evidence level2
citationJohnen Jana (2026)
sourceEffects of regular consumption of a β-glucan-rich oyster mushroom powder on cholesterol metabolism in adults with moderately elevated LDL-cholesterol concentrations: a double-blind randomized controlled trial
topicBeta-Sitosterol Cholesterol Randomized Trial
claimHowever, owing to methodological limitations (e.g., the lack of randomization and blinding) and high risk of bias, evidence supporting the beneficial effects of PO intake on the lipid profile remains weak [].
evidence level2
citationJohnen Jana (2026)
sourceEffects of regular consumption of a β-glucan-rich oyster mushroom powder on cholesterol metabolism in adults with moderately elevated LDL-cholesterol concentrations: a double-blind randomized controlled trial
topicBeta-Sitosterol Cholesterol Randomized Trial
claim1 Atherosclerotic cardiovascular diseases (ASCVD) remain the leading causes of death worldwide.
evidence level2
citationJohnen Jana (2026)
sourceEffects of regular consumption of a β-glucan-rich oyster mushroom powder on cholesterol metabolism in adults with moderately elevated LDL-cholesterol concentrations: a double-blind randomized controlled trial
topicBeta-Sitosterol Cholesterol Randomized Trial
claimPhytosterols, a form of naturally occurring substance structurally related to cholesterol, have been getting considerable interest due to their possible anticancer property.
evidence level2
citationShahbaz M (2026)
sourceAnticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials.
topicBeta-Sitosterol Cholesterol Randomized Trial
claimThey have multifactorial modes of action such as antioxidant, anti-inflammatory, and apoptotic, which render them useful in the prevention and treatment of prostate, breast, colon, bladder, and skin cancer.
evidence level2
citationShahbaz M (2026)
sourceAnticancer Molecular Mechanisms of Phytosterols: An Updated Review on Clinical Trials.