topicBeta Glucan Stress Randomized Trial
claimBy interacting with innate pattern recognition receptors (PRRs), including Dectin-1 and Toll-like receptors (TLRs), expressed on gut-associated lymphoid tissue (GALT) and immune cells, β-1,3-glucans regulate both innate and adaptive immune responses [,].
evidence level4
citationSamiksha Fnu (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation
topicBeta Glucan Stress Randomized Trial
claimTable 2 A summary of β-glucans derived from different fungal sources and their associated therapeutic properties is provided in.
evidence level4
citationSamiksha Fnu (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation
topicBeta Glucan Stress Randomized Trial
claimAlthough multiple receptor systems are involved, the overall framework is conserved and relies on the detection of pathogen-associated molecular patterns (PAMPs) by PRR families, including Dectin-1, TLRs, complement receptor 3 (CR3), lactosylceramide (LacCer), and scavenger receptors (SRs).
evidence level4
citationSamiksha Fnu (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation
topicBeta Glucan Stress Randomized Trial
claim1 2 2 Glucans are polysaccharides composed entirely of glucose monomers and are generally classified into three structural categories: α-glucans, β-glucans, and mixed α, β-glucans [,].
evidence level4
citationSamiksha Fnu (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation
topicBeta Glucan Stress Randomized Trial
claimHowever, most clinical trials to date have focused on moderate to high doses of YBG (≥250 mg/day) over short to moderate durations (ranging from 7 days to 3 months).Evidence on the efficacy, tolerability, and sustainability of low-dose supplementation remains scarce, despite its practical advantages for daily, long-term use.
evidence level4
citationHabibullah Nur Nadia Mohamad (2026)
sourceLow-dose of yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults
topicBeta Glucan Stress Randomized Trial
claimThe modest declines across all groups suggest a trend toward improved vitality but no differential treatment effect.
evidence level4
citationHabibullah Nur Nadia Mohamad (2026)
sourceLow-dose of yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults
topicBeta Glucan Stress Randomized Trial
claimFor (A–F) and (H), lower scores indicate reduced negative mood states; for (G) (Vigor), higher scores indicate increased energy and vitality.
evidence level4
citationHabibullah Nur Nadia Mohamad (2026)
sourceLow-dose of yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults
topicBeta Glucan Stress Randomized Trial
claimTo address this gap, the present randomized, double-blind, placebo-controlled trial investigated the effects of 12-week supplementation with low-dose (120 mg) and moderate-dose (204 mg) YBG among moderately stressed adults.
evidence level4
citationHabibullah Nur Nadia Mohamad (2026)
sourceLow-dose of yeast beta-glucan on respiratory symptoms and psychological well-being in moderately stressed adults