topicBeta Glucan Gut Microbiome Randomized Trial
claimOwing to the limited number of human and mechanistic studies, we recommend a multidisciplinary approach integrating expertise in food processing, analytical chemistry, and microbiology to further elucidate their potential to improve health through gut microbiome modulation.
evidence level3
citationKeigler Johanna I. (2026)
sourceMyco-foods and the gut microbiome: impacts of mycelial extracts, biomass, and mold-fermented foods
topicBeta Glucan Gut Microbiome Randomized Trial
claimSpecifically, a longitudinal study examined for changes to the gut microbiota and metabolites of 15 healthy subjects who consumed 4.5 g CG daily for three weeks.The intake of CG was associated with changes in the relative abundance of nine microbial genera, including significant increases in, andand decreases inandIncreases in the fecal levels of the SCFAs butyric, caproic, and isovaleric acids were also reported.
evidence level3
citationKeigler Johanna I. (2026)
sourceMyco-foods and the gut microbiome: impacts of mycelial extracts, biomass, and mold-fermented foods
topicBeta Glucan Gut Microbiome Randomized Trial
claimSupplementation with H(via water) was associated with improved glucose and lipid metabolism in a clinical trial.Thus, hydrogen production may be one mechanism through which fungal fiber fermentation by the gut microbiota influences host metabolism.
evidence level3
citationKeigler Johanna I. (2026)
sourceMyco-foods and the gut microbiome: impacts of mycelial extracts, biomass, and mold-fermented foods
topicBeta Glucan Gut Microbiome Randomized Trial
claimMany compounds with medicinal importance (such as antibiotics, immunosuppressants, and statins) have been extracted or derived from molds, includingandspecies.However, mycelial extracts from edible molds are also of interest because of their high fiber and other bioactive contents.
evidence level3
citationKeigler Johanna I. (2026)
sourceMyco-foods and the gut microbiome: impacts of mycelial extracts, biomass, and mold-fermented foods
topicBeta Glucan Gut Microbiome Randomized Trial
claimPreclinical and emerging clinical evidence supports broad therapeutic potential across multiple disease domains, including inflammatory bowel disease, metabolic disorders, respiratory infections, and cancer.
evidence level4
citationSamiksha F (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation.
topicBeta Glucan Gut Microbiome Randomized Trial
claimFungal β-1,3-glucans are structurally conserved polysaccharide components of the fungal cell wall that exhibit potent immunomodulatory activity.
evidence level4
citationSamiksha F (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation.
topicBeta Glucan Gut Microbiome Randomized Trial
claimThese molecules are recognized by pattern recognition receptors, Toll-like receptors, complement receptor 3, lactosylceramide, scavenger receptors, and EphA2.
evidence level4
citationSamiksha F (2026)
sourceFungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation.