topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimImportantly, mechanistic evidence indicates that performance loss during repeated maximal efforts reflects an integrated disturbance in muscle function—encompassing substrate availability, metabolite/ionic perturbations, excitation–contraction coupling, and only later, more pronounced acid–base disruption—rather than a single dominant metabolite (–).
evidence level1
citationLiang Weibao (2026)
sourceNo ergogeniceffect of β-alanine on repeated sprint ability: a systematic review and multilevel meta-analysis of randomized controlled trials
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimConsistent with this mechanism, contemporary meta-analytic evidence indicates the most reproducible ergogenic effects in high-intensity exercise tasks of approximately 1–4 min, where acid–base perturbation is more likely to be performance-limiting ().
evidence level1
citationLiang Weibao (2026)
sourceNo ergogeniceffect of β-alanine on repeated sprint ability: a systematic review and multilevel meta-analysis of randomized controlled trials
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimBiopsy-based repeated-sprint experiments show that recovery of subsequent sprint performance is tightly associated with PCr resynthesis even when muscle pH remains depressed, suggesting that acid–base normalization is not a prerequisite for short-term restoration of repeated-sprint capacity (,).
evidence level1
citationLiang Weibao (2026)
sourceNo ergogeniceffect of β-alanine on repeated sprint ability: a systematic review and multilevel meta-analysis of randomized controlled trials
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claim1 2 3 4 5 7 Repeated sprint ability (RSA) is a defining performance attribute in intermittent sports, characterized by repeated maximal or near-maximal efforts separated by brief recovery, with an ensuing decline in mechanical output across bouts (,).
evidence level1
citationLiang Weibao (2026)
sourceNo ergogeniceffect of β-alanine on repeated sprint ability: a systematic review and multilevel meta-analysis of randomized controlled trials
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimThis review excluded supplements where the proposed ergogenic mechanism did not involve failure at high intensity; studies with primarily clinical evidence and not focused on sports performance; or when available evidence did not support a clear mechanistic link with the framework.
evidence level3
citationStout Jeffrey R. (2026)
sourceDelaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimThe review did not perform risk-of-bias assessments or grading of evidence, nor did it pool data using meta-analysis; therefore, any conclusions drawn should be regarded as hypothesis-generating rather than exhaustive.
evidence level3
citationStout Jeffrey R. (2026)
sourceDelaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimTo minimize overinterpretation of the proposed model and highlight tractable research avenues, this review demarcated areas supported by direct evidence, those inferred through plausibility, and those not yet addressed.
evidence level3
citationStout Jeffrey R. (2026)
sourceDelaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition
topicBeta-Alanine Muscle Carnosine Meta-Analysis
claimTask failure during high-intensity exercise is not usually attributable to a single event.
evidence level3
citationStout Jeffrey R. (2026)
sourceDelaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition