topicBerberine Supplementation Lipid Meta-Analysis
claimAlthough preclinical evidence is promising, no systematic review has previously synthesised evidence from randomised controlled trials (RCTs) in humans.
evidence level1
citationCandrea AR (2026)
sourceThe Integrative Role of Berberine in Gut Microbiota Modulation and Cardiometabolic Outcomes: A Systematic Review of Randomised Clinical Trials.
topicBerberine Supplementation Lipid Meta-Analysis
claimThis review aimed to evaluate the effects of berberine supplementation on gut microbiota and to explore associated cardiometabolic, inflammatory, and immunological changes.
evidence level1
citationCandrea AR (2026)
sourceThe Integrative Role of Berberine in Gut Microbiota Modulation and Cardiometabolic Outcomes: A Systematic Review of Randomised Clinical Trials.
topicBerberine Supplementation Lipid Meta-Analysis
claimBackground/Aim : Berberine, an isoquinoline alkaloid widely used in traditional medicine, has attracted considerable interest for its capacity to modulate the gut microbiota and improve cardiometabolic outcomes.
evidence level1
citationCandrea AR (2026)
sourceThe Integrative Role of Berberine in Gut Microbiota Modulation and Cardiometabolic Outcomes: A Systematic Review of Randomised Clinical Trials.
topicBerberine Supplementation Lipid Meta-Analysis
claimIn vivo experiments showed that BBR improved bone mineral density and trabecular microarchitecture, and upregulated osteogenic markers (COL1 and BMP2).
evidence level4
citationChao S (2026)
sourceBerberine Attenuates Glucocorticoid-Induced Bone Loss in Mice: Associated with the Gut Microbiota-Glycerophospholipid Metabolic Axis.
topicBerberine Supplementation Lipid Meta-Analysis
claimOverall, these findings suggest that the attenuation of bone loss by BBR may be associated with alterations in the gut microbiota-glycerophospholipid metabolic axis, supporting its potential as a functional food ingredient for bone health.
evidence level4
citationChao S (2026)
sourceBerberine Attenuates Glucocorticoid-Induced Bone Loss in Mice: Associated with the Gut Microbiota-Glycerophospholipid Metabolic Axis.
topicBerberine Supplementation Lipid Meta-Analysis
claimDietary supplementation with functional nutrients is a safe strategy to improve bone health.
evidence level4
citationChao S (2026)
sourceBerberine Attenuates Glucocorticoid-Induced Bone Loss in Mice: Associated with the Gut Microbiota-Glycerophospholipid Metabolic Axis.
topicBerberine Supplementation Lipid Meta-Analysis
claimThis study aimed to investigate the ameliorative effects of Berberine (BBR) on dexamethasone-induced bone loss in mice and its potential mechanisms.
evidence level4
citationChao S (2026)
sourceBerberine Attenuates Glucocorticoid-Induced Bone Loss in Mice: Associated with the Gut Microbiota-Glycerophospholipid Metabolic Axis.