evidence table

Avocado Lipid Profile Randomized Trial Evidence Table

Structured evidence table for Avocado Lipid Profile Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Avocado Lipid Profile Randomized TrialThe HAT was a multicenter trial with 4 clinical centers and a coordinating center designed to evaluate the effect of consuming 1 avocado per day on visceral adiposity (primary endpoint) and other cardiometabolic risk factors (secondary endpoints) in 1008 participants [,].4Kris-Etherton Penny M (2026)The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
Avocado Lipid Profile Randomized TrialEffects of avocado consumption on diet quality  Penn State 5 Examine changes in the HEI-2015 after a food-based intervention and assess the associations between HEI-2015 change and intervention effects on cardiometabolic risk–related outcomes [].4Kris-Etherton Penny M (2026)The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
Avocado Lipid Profile Randomized TrialDaily consumption of 1 avocado within the AD significantly reduced glycemic load, but not glycemic index, without requiring significant dietary changes.4Kris-Etherton Penny M (2026)The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
Avocado Lipid Profile Randomized TrialMany clinical trials examining the health effects of single foods have been conducted, and the findings have informed recommendations for healthy eating/dietary patterns.4Kris-Etherton Penny M (2026)The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
Avocado Lipid Profile Randomized TrialBackground Avocado consumption has been associated with improvements in diet quality and cardiometabolic risk factors, but effects on serum metabolite profiles remain underexplored.4Matthan NR (2026)Serum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
Avocado Lipid Profile Randomized TrialPre-post intervention changes in metabolites, cardiometabolic risk factors (blood pressure, lipid profile, glucose, insulin, high-sensitivity C-reactive protein), visceral adipose tissue volume, and hepatic fat fraction were evaluated using Wilcoxon tests.4Matthan NR (2026)Serum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
Avocado Lipid Profile Randomized TrialConclusions Avocado intake was associated with subtle shifts in serum metabolites related to lipid, carbohydrate, and amino acid metabolism, with weak effects on visceral adipose tissue volume, plasma triglycerides, and total cholesterol concentrations.4Matthan NR (2026)Serum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
Avocado Lipid Profile Randomized TrialMethods Secondary analysis was conducted using untargeted metabolomics to assess fasting serum metabolite profiles at baseline (preintervention) and 6 months (postintervention) in a subset of participants with abdominal obesity from the HAT (Habitual Diet and Avocado Trial), who were randomized to the avocado group (n = 120; 70% women; 49 ± 13 years of age; body mass index 33.1 ± 5.7 kg/m 2 ).4Matthan NR (2026)Serum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
topicAvocado Lipid Profile Randomized Trial
claimThe HAT was a multicenter trial with 4 clinical centers and a coordinating center designed to evaluate the effect of consuming 1 avocado per day on visceral adiposity (primary endpoint) and other cardiometabolic risk factors (secondary endpoints) in 1008 participants [,].
evidence level4
citationKris-Etherton Penny M (2026)
sourceThe Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
topicAvocado Lipid Profile Randomized Trial
claimEffects of avocado consumption on diet quality  Penn State 5 Examine changes in the HEI-2015 after a food-based intervention and assess the associations between HEI-2015 change and intervention effects on cardiometabolic risk–related outcomes [].
evidence level4
citationKris-Etherton Penny M (2026)
sourceThe Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
topicAvocado Lipid Profile Randomized Trial
claimDaily consumption of 1 avocado within the AD significantly reduced glycemic load, but not glycemic index, without requiring significant dietary changes.
evidence level4
citationKris-Etherton Penny M (2026)
sourceThe Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
topicAvocado Lipid Profile Randomized Trial
claimMany clinical trials examining the health effects of single foods have been conducted, and the findings have informed recommendations for healthy eating/dietary patterns.
evidence level4
citationKris-Etherton Penny M (2026)
sourceThe Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
topicAvocado Lipid Profile Randomized Trial
claimBackground Avocado consumption has been associated with improvements in diet quality and cardiometabolic risk factors, but effects on serum metabolite profiles remain underexplored.
evidence level4
citationMatthan NR (2026)
sourceSerum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
topicAvocado Lipid Profile Randomized Trial
claimPre-post intervention changes in metabolites, cardiometabolic risk factors (blood pressure, lipid profile, glucose, insulin, high-sensitivity C-reactive protein), visceral adipose tissue volume, and hepatic fat fraction were evaluated using Wilcoxon tests.
evidence level4
citationMatthan NR (2026)
sourceSerum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
topicAvocado Lipid Profile Randomized Trial
claimConclusions Avocado intake was associated with subtle shifts in serum metabolites related to lipid, carbohydrate, and amino acid metabolism, with weak effects on visceral adipose tissue volume, plasma triglycerides, and total cholesterol concentrations.
evidence level4
citationMatthan NR (2026)
sourceSerum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.
topicAvocado Lipid Profile Randomized Trial
claimMethods Secondary analysis was conducted using untargeted metabolomics to assess fasting serum metabolite profiles at baseline (preintervention) and 6 months (postintervention) in a subset of participants with abdominal obesity from the HAT (Habitual Diet and Avocado Trial), who were randomized to the avocado group (n = 120; 70% women; 49 ± 13 years of age; body mass index 33.1 ± 5.7 kg/m 2 ).
evidence level4
citationMatthan NR (2026)
sourceSerum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.

Source documents

  1. The Habitual Diet and Avocado Trial (HAT): A Collaborative Multicenter Model for Large-Scale, Privately Funded Nutrition Research Consortia
  2. Serum Metabolite Profiles in Adults With Abdominal Obesity in Response to Consuming 1 Avocado Daily for 6 Months: An Exploratory Analysis.