evidence table

Arginine Exercise Performance Randomized Trial Evidence Table

Structured evidence table for Arginine Exercise Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Arginine Exercise Performance Randomized Trial1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Arginine Exercise Performance Randomized Trial1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Arginine Exercise Performance Randomized TrialLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Arginine Exercise Performance Randomized TrialIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.3Wang Xiaolan (2026)Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
Arginine Exercise Performance Randomized TrialThrough its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–).4Uçar Halil (2026)Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
Arginine Exercise Performance Randomized TrialHowever, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established.4Uçar Halil (2026)Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
Arginine Exercise Performance Randomized TrialNo significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period.4Uçar Halil (2026)Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
Arginine Exercise Performance Randomized Trial1 2 3 Taekwondo is a full-contact martial art in which successful performance is largely determined by the execution of high-force kicking techniques directed to the trunk protector or head of the opponent (,).4Uçar Halil (2026)Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicArginine Exercise Performance Randomized Trial
claim1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicArginine Exercise Performance Randomized Trial
claim1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence ().
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicArginine Exercise Performance Randomized Trial
claimLow circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,).
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicArginine Exercise Performance Randomized Trial
claimIn this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials.
evidence level3
citationWang Xiaolan (2026)
sourceGlycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
topicArginine Exercise Performance Randomized Trial
claimThrough its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–).
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicArginine Exercise Performance Randomized Trial
claimHowever, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established.
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicArginine Exercise Performance Randomized Trial
claimNo significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period.
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicArginine Exercise Performance Randomized Trial
claim1 2 3 Taekwondo is a full-contact martial art in which successful performance is largely determined by the execution of high-force kicking techniques directed to the trunk protector or head of the opponent (,).
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes

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Source documents

  1. Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults
  2. Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes