sleep

Amino Acid Glycine Sleep Meta-Analysis Evidence Table

Structured evidence table for Amino Acid Glycine Sleep Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Amino Acid Glycine Sleep Meta-AnalysisKCNH voltage-gated potassium channels regulate neuronal excitability, yet how their hallmark cyclic nucleotide-binding homology domains (CNBHDs) influence channel gating to regulate behavior remains unclear.4Huang X (2026)Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep.
Amino Acid Glycine Sleep Meta-AnalysisUsing an unbiased forward genetic screen in Caenorhabditis elegans, we identified a gain-of-function mutation in the EAG-subfamily KCNH channel EGL-2 that suppresses sleep.4Huang X (2026)Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep.
Amino Acid Glycine Sleep Meta-AnalysisThis metabolic reprogramming is associated with exacerbated oxidative stress, neuroinflammation, and accelerated pathological progression.4Shao Y (2026)Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
Amino Acid Glycine Sleep Meta-AnalysisThese findings provide multiomic evidence that clarifies the molecular heterogeneity in PD and highlights gut microbiota-driven dysfunction as a key contributor to both the iRBD and RBD-PD subtypes.4Shao Y (2026)Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
Amino Acid Glycine Sleep Meta-AnalysisRapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients.4Shao Y (2026)Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
Amino Acid Glycine Sleep Meta-AnalysisPD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more severe motor and nonmotor symptoms, prominent autonomic dysfunction, and accelerated disease progression; however, its underlying pathogenesis remains poorly understood.4Shao Y (2026)Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
topicAmino Acid Glycine Sleep Meta-Analysis
claimKCNH voltage-gated potassium channels regulate neuronal excitability, yet how their hallmark cyclic nucleotide-binding homology domains (CNBHDs) influence channel gating to regulate behavior remains unclear.
evidence level4
citationHuang X (2026)
sourceForward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep.
topicAmino Acid Glycine Sleep Meta-Analysis
claimUsing an unbiased forward genetic screen in Caenorhabditis elegans, we identified a gain-of-function mutation in the EAG-subfamily KCNH channel EGL-2 that suppresses sleep.
evidence level4
citationHuang X (2026)
sourceForward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep.
topicAmino Acid Glycine Sleep Meta-Analysis
claimThis metabolic reprogramming is associated with exacerbated oxidative stress, neuroinflammation, and accelerated pathological progression.
evidence level4
citationShao Y (2026)
sourceDistinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
topicAmino Acid Glycine Sleep Meta-Analysis
claimThese findings provide multiomic evidence that clarifies the molecular heterogeneity in PD and highlights gut microbiota-driven dysfunction as a key contributor to both the iRBD and RBD-PD subtypes.
evidence level4
citationShao Y (2026)
sourceDistinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
topicAmino Acid Glycine Sleep Meta-Analysis
claimRapid eye movement sleep behavior disorder (RBD) is the most specific prodromal marker of Parkinson's disease (PD), affecting 40-50% of PD patients.
evidence level4
citationShao Y (2026)
sourceDistinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.
topicAmino Acid Glycine Sleep Meta-Analysis
claimPD with RBD (RBD-PD) represents a clinically aggressive subtype characterized by more severe motor and nonmotor symptoms, prominent autonomic dysfunction, and accelerated disease progression; however, its underlying pathogenesis remains poorly understood.
evidence level4
citationShao Y (2026)
sourceDistinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.

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GuideThe Evidence-Based Sleep Stack: Magnesium, Glycine & L-TheanineLegacy library material — check the original sources.GuideBest Magnesium Glycinate supplements for sleepLegacy library material — check the original sources.AnswerDoes Amino Acid Glycine Sleep Meta-Analysis work?Legacy library material — check the original sources.AnswerIs Amino Acid Glycine Sleep Meta-Analysis safe?Legacy library material — check the original sources.AnswerWhat does the evidence say about Amino Acid Glycine Sleep Meta-Analysis?Legacy library material — check the original sources.AnswerDoes Glycine Supplementation Sleep Quality Randomized Trial work?Legacy library material — check the original sources.

Source documents

  1. Forward genetics reveals a conserved CNBHD-CNBHD interface that restrains EAG channel activation to regulate sleep.
  2. Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder.