Structured evidence table for Alpha-Lipoic Acid Metabolic Markers Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Results: All three compounds were associated with shifts in microbial composition compared to the HFD-only group. | 4 | Kim HJ (2026) | Effect of Alpha-Lipoic Acid, Betaine, and L-Carnitine Supplementation on Gut Microbiota and Obesity Biomarkers in Mice. |
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Background/Objectives: This exploratory study ( n = 6 per group) investigated the associations between supplementation with α-lipoic acid (AL), betaine (BT), and L-carnitine (LC) and gut microbiota composition in a high-fat diet (HFD)-induced obesity mouse model. | 4 | Kim HJ (2026) | Effect of Alpha-Lipoic Acid, Betaine, and L-Carnitine Supplementation on Gut Microbiota and Obesity Biomarkers in Mice. |
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Methods: Four-week-old male C57BL/6J mice were fed a control diet (10% fat), HFD (60% fat), or HFD supplemented with AL, BT, or LC (300 mg/kg BW/day) for nine weeks. | 4 | Kim HJ (2026) | Effect of Alpha-Lipoic Acid, Betaine, and L-Carnitine Supplementation on Gut Microbiota and Obesity Biomarkers in Mice. |
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Conclusion These findings clearly demonstrate that ALA confers manifold hepatoprotective effects against CSD-induced dysfunction by significantly restoring redox balance, decreasing hepatic inflammation, suppressing apoptotic and ferroptotic signaling, thereby successfully preserving metabolic activity. | 4 | Chang HM (2026) | Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury. |
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Objective Chronic sleep deprivation (CSD) is a major public health issue that causes metabolic dysfunction by disrupting redox homeostasis and triggering hepatic inflammation. | 4 | Chang HM (2026) | Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury. |
| Alpha-Lipoic Acid Metabolic Markers Meta-Analysis | Given the strong anti-oxidative and anti-inflammatory properties of alpha lipoic acid (ALA), this study aims to determine whether exogenous ALA supplementation would provide hepatoprotection and therefore, maintain the metabolic activity following CSD. | 4 | Chang HM (2026) | Manifold hepatoprotective actions of α-lipoic acid on metabolic function through redox regulation, inflammatory modulation, and anti-apoptosis after chronic sleep-deprived injury. |
Source documents