topicAloe Vera Gut Health Randomized Trial
claimYoung adults, particularly females, have a higher prevalence, which has increased substantially over the past decades [].
evidence level2
citationPastras Ploutarchos (2026)
sourcePlant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines
topicAloe Vera Gut Health Randomized Trial
claimMore specifically, the presence of recurrent abdominal pain, on average, at least 1 day per week in the last 3 months, associated with two or more of the following: symptoms related to defecation, a change in stool frequency, or a change in stool form [].
evidence level2
citationPastras Ploutarchos (2026)
sourcePlant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines
topicAloe Vera Gut Health Randomized Trial
claimIBS is associated with reduced engagement in daily activities, increased work absenteeism, and impaired functioning, thereby increasing the global healthcare burden [].
evidence level2
citationPastras Ploutarchos (2026)
sourcePlant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines
topicAloe Vera Gut Health Randomized Trial
claim1 2 1 3 1 4 5 Disorders of gut–brain interaction (DGBIs) are functional gastrointestinal conditions characterized by a complex interplay between the gut and the brain [].
evidence level2
citationPastras Ploutarchos (2026)
sourcePlant-Derived Treatments for IBS: Clinical Outcomes, Mechanistic Insights, and Their Position in International Guidelines
topicAloe Vera Gut Health Randomized Trial
claimAs shown in, the global burden of periodontal disease has progressively increased from 1990 to 2023, with a marked rise across Africa and Asia, highlighting widening regional disparities and the growing need for targeted preventive strategies ().
evidence level3
citationRath Pranita (2026)
sourceTraditional medicine and natural product based therapeutics in gingivitis management and microbial interactions
topicAloe Vera Gut Health Randomized Trial
claimClinical studies show that the addition of chlorhexidine chip therapy to scaling and root planning yields substantial benefits, including greater reductions in probing depth, enhanced clinical attachment gains and improved plaque control compared to scaling and root planning performed independently ().
evidence level3
citationRath Pranita (2026)
sourceTraditional medicine and natural product based therapeutics in gingivitis management and microbial interactions
topicAloe Vera Gut Health Randomized Trial
claimAfter four to six weeks of use, chlorhexidine mouth rinse reduced gingivitis by 0.21 on the Gingival Index (0 to 3 scale) compared to placebo, control or no mouth rinse, with a similar effect size found for reducing gingivitis at 6 months ().
evidence level3
citationRath Pranita (2026)
sourceTraditional medicine and natural product based therapeutics in gingivitis management and microbial interactions
topicAloe Vera Gut Health Randomized Trial
claimHamid et al., 2021 Fan et al., 2021 Alfahmi et al., 2024 Gingivitis represents the most prevalent plaque-induced inflammatory oral condition affecting millions worldwide.
evidence level3
citationRath Pranita (2026)
sourceTraditional medicine and natural product based therapeutics in gingivitis management and microbial interactions