topicAged Garlic Extract Blood Pressure Meta-Analysis
claim1 1 2 2 3 4 1 According to the World Health Organization (WHO), the global prevalence of systemic arterial hypertension (SAH) has increased significantly, rising from 650 million cases in 1990 to 1.13 billion in 2019.
evidence level3
citationCiafrino Agnes (2026)
sourceUnlocking the Potential of Nutritional Approaches and Bioactive Compounds to Modulate Oxidative Stress and Inflammation in Systemic Arterial Hypertension
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimHypertension causes target organ damage, increases the risk of cardiovascular, cerebrovascular, and renal diseases [,], and remains one of the leading causes of premature death worldwide [].
evidence level3
citationCiafrino Agnes (2026)
sourceUnlocking the Potential of Nutritional Approaches and Bioactive Compounds to Modulate Oxidative Stress and Inflammation in Systemic Arterial Hypertension
topicAged Garlic Extract Blood Pressure Meta-Analysis
claim5 4 6 7 8 Although advanced age and genetic predisposition are non‐modifiable risk factors, lifestyle choices play a significant role in the development of hypertension.
evidence level3
citationCiafrino Agnes (2026)
sourceUnlocking the Potential of Nutritional Approaches and Bioactive Compounds to Modulate Oxidative Stress and Inflammation in Systemic Arterial Hypertension
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimCurrent estimates suggest that 1.28 billion adults aged 30–79 years globally are affected by hypertension [].
evidence level3
citationCiafrino Agnes (2026)
sourceUnlocking the Potential of Nutritional Approaches and Bioactive Compounds to Modulate Oxidative Stress and Inflammation in Systemic Arterial Hypertension
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimExperimental and clinical evidence suggest that reduced H₂S bioavailability contributes to hypertension and associated vascular dysfunction.
evidence level3
citationNikolov NN (2026)
sourceThe Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review.
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimThis study aimed to map and synthesize the breadth of mechanistic, preclinical, and clinical evidence on the role of H₂S in the pathophysiology and therapeutic modulation of hypertension.
evidence level3
citationNikolov NN (2026)
sourceThe Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review.
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimThis scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline.
evidence level3
citationNikolov NN (2026)
sourceThe Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review.
topicAged Garlic Extract Blood Pressure Meta-Analysis
claimHydrogen sulfide (H₂S) is an endogenous gasotransmitter involved in vascular regulation, endothelial signaling, oxidative balance, and inflammatory pathways relevant to blood pressure control.
evidence level3
citationNikolov NN (2026)
sourceThe Role of Hydrogen Sulfide in the Pathophysiology and Therapeutic Modulation of Hypertension: A Scoping Review.