What does the evidence say about Sesame Lignans Cholesterol Randomized Trial?

Updated October 2026

Quick Answer

Sesame Lignans Cholesterol Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: The harvested area (which has expanded from 5.0 million hectares in 1961 to 13.97 million ha in 2022) and the production of sesame have increased over the last few decades (1.4 million tonnes in 1961 to 7.4 million tonnes in 2022) [,].

Key Takeaways

  • 01The harvested area (which has expanded from 5.0 million hectares in 1961 to 13.97 million ha in 2022) and the production of sesame have increased over the last few decades (1.4 million tonnes in 1961 to 7.4 million tonnes in 2022) [,]. [Mostashari Parisa (2024)]
  • 02According to Ahmad and Ghosh’s (2020) research, sesame seeds possess a high nutrient content that may benefit the immune system significantly and potentially mitigate the risk of health complications associated with COVID-19. [Mostashari Parisa (2024)]
  • 03Hsu and Parthasarathy [] have indicated that the consumption of sesame oil can reduce levels of low-density lipoprotein (LDL) and decrease the risk of atherosclerosis and cardiovascular diseases. [Mostashari Parisa (2024)]
  • 04Sesamum indicum ajonjoli hu ma gergelim goma sesame til konjed 1 2 3 4 5 5 6 7 8 7 9 7 8 10 11 12 13 14 15 Sesame (L.) is a plant classified under the Pedaliaceae family and is often called the “seed of immortality.” This plant is an erect annual herb that has different names across various cultures, including(Spanish),(Chinese),(Portuguese),(Japanese),(French),(Hindi), and(Persian) [,,]. [Mostashari Parisa (2024)]
The current Migaku evidence database contains 2 reusable source documents for Sesame Lignans Cholesterol Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - The harvested area (which has expanded from 5.0 million hectares in 1961 to 13.97 million ha in 2022) and the production of sesame have increased over the last few decades (1.4 million tonnes in 1961 to 7.4 million tonnes in 2022) [,]. [Mostashari Parisa (2024); evidence level 3] - According to Ahmad and Ghosh’s (2020) research, sesame seeds possess a high nutrient content that may benefit the immune system significantly and potentially mitigate the risk of health complications associated with COVID-19. [Mostashari Parisa (2024); evidence level 3] - Hsu and Parthasarathy [] have indicated that the consumption of sesame oil can reduce levels of low-density lipoprotein (LDL) and decrease the risk of atherosclerosis and cardiovascular diseases. [Mostashari Parisa (2024); evidence level 3] - Sesamum indicum ajonjoli hu ma gergelim goma sesame til konjed 1 2 3 4 5 5 6 7 8 7 9 7 8 10 11 12 13 14 15 Sesame (L.) is a plant classified under the Pedaliaceae family and is often called the “seed of immortality.” This plant is an erect annual herb that has different names across various cultures, including(Spanish),(Chinese),(Portuguese),(Japanese),(French),(Hindi), and(Persian) [,,]. [Mostashari Parisa (2024); evidence level 3] - Furthermore, sesamin significantly reduced the levels of 24S-hydroxycholesterol in rat plasma and brain tissues, and down-regulated the protein expressions of CYP46A1, NMDAR2A, NMDAR2B, and HMGCR. [Du J (2022); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Sesame Seeds: A Nutrient-Rich Superfood
  2. Characterization of three naturally occurring lignans, sesamol, sesamolin, and sesamin, as potent inhibitors of human cytochrome P450 46A1: Implications for treating excitatory neurotoxicity.