Does Resveratrol Skin Health Randomized Trial work?

The current Migaku evidence database contains 2 reusable source documents for Resveratrol Skin Health Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Results indicated significantly reduced wrinkle scores in the A/A Group compared to the P/P Group at week 8. [Rao A (2025); evidence level 2] - All treatment groups showed increased sebum levels, with the active topical groups (P/A and A/A Groups) having significantly higher U-zone sebum at week 8 compared to placebo topical groups (P/P and A/P Groups). [Rao A (2025); evidence level 2] - Serum trans-resveratrol conjugate levels increased significantly in the A/P and A/A Groups at week 4 and 8. [Rao A (2025); evidence level 2] - Introduction This double-blind, randomised, placebo-controlled clinical study evaluated the effects of trans-resveratrol on skin health. [Rao A (2025); evidence level 2] - Notably, the concentration of PIC required for certain in vitro activities remains higher than those typically achieved in vivo, and the current evidence base for PIC in human skin is considerably less developed than that for resveratrol. [Zhang Dian (2026); evidence level 3] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.