Quick Answer
Probiotics Skin Health Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: Standard therapy often relies on antibiotics, but the long-term use has increased antibiotic resistance, including in Indonesia.
Key Takeaways
- 01Standard therapy often relies on antibiotics, but the long-term use has increased antibiotic resistance, including in Indonesia. [Lestari K (2026)]
- 02Background Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes , which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. [Lestari K (2026)]
- 03Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. [Lestari K (2026)]
- 04Elevated reactive oxygen species (ROS) also play a key role, as increased ROS levels are found in patients with rosacea []. [Muacevic Alexander (2026)]
The current Migaku evidence database contains 2 reusable source documents for Probiotics Skin Health Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove.
- Standard therapy often relies on antibiotics, but the long-term use has increased antibiotic resistance, including in Indonesia. [Lestari K (2026); evidence level 2]
- Background Acne vulgaris is a chronic inflammatory condition primarily caused by Cutibacterium acnes , which disrupts skin homeostasis, thereby triggering immune responses and sebum metabolism. [Lestari K (2026); evidence level 2]
- Dysbiosis is an imbalance in the skin and gut microbiota identified as a significant factor contributing to acne progression. [Lestari K (2026); evidence level 2]
- Elevated reactive oxygen species (ROS) also play a key role, as increased ROS levels are found in patients with rosacea []. [Muacevic Alexander (2026); evidence level 4]
- Mendelian randomization studies have linked certain bacterial taxa, including uncategorized[] andspecies [], to an increased risk of rosacea, while other taxa appear to confer a protective effect []. [Muacevic Alexander (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources