What does the evidence say about Phosphatidylserine Cognition Randomized Trial?

Updated May 2026

Quick Answer

Phosphatidylserine Cognition Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: This study aimed to evaluate the effects of PS on core symptoms and associated behavioral problems in children with ADHD.

Key Takeaways

  • 01This study aimed to evaluate the effects of PS on core symptoms and associated behavioral problems in children with ADHD. [Shen Z (2026)]
  • 02In contrast, the PS group demonstrated significant reductions in internalizing (M = 1.83, SD = 3.28, p < 0.05, d = 0.56) and externalizing behaviors (M = 3.38, SD = 5.20, p < 0.05, d = 0.65), whereas the atomoxetine group improved only in externalizing behaviors (M = 2.54, SD = 5.42, p < 0.05, d = 0.47). [Shen Z (2026)]
  • 03Phosphatidylserine was not associated with significant improvements in core ADHD symptoms but was associated with reductions in internalizing and externalizing behavioral problems, particularly in reducing aggression. [Shen Z (2026)]
  • 04Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by attention deficit, hyperactivity, and various internalizing and externalizing behavioral problems. [Shen Z (2026)]
The current Migaku evidence database contains 2 reusable source documents for Phosphatidylserine Cognition Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - This study aimed to evaluate the effects of PS on core symptoms and associated behavioral problems in children with ADHD. [Shen Z (2026); evidence level 4] - In contrast, the PS group demonstrated significant reductions in internalizing (M = 1.83, SD = 3.28, p < 0.05, d = 0.56) and externalizing behaviors (M = 3.38, SD = 5.20, p < 0.05, d = 0.65), whereas the atomoxetine group improved only in externalizing behaviors (M = 2.54, SD = 5.42, p < 0.05, d = 0.47). [Shen Z (2026); evidence level 4] - Phosphatidylserine was not associated with significant improvements in core ADHD symptoms but was associated with reductions in internalizing and externalizing behavioral problems, particularly in reducing aggression. [Shen Z (2026); evidence level 4] - Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder in children, characterized by attention deficit, hyperactivity, and various internalizing and externalizing behavioral problems. [Shen Z (2026); evidence level 4] - Phosphatidylserine Supplementation on Psychomotor Speed among Healthy Adults with Subjective Cognitive Declines [Phosphatidylserine Supplementation on Psychomotor Speed among Healthy Adults with Subjective Cognitive Declines (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. The effect of phosphatidylserine on behavioral problems in children with attention deficit hyperactivity disorder.
  2. Phosphatidylserine Supplementation on Psychomotor Speed among Healthy Adults with Subjective Cognitive Declines