Quick Answer
Elderberry Sleep Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: In an exploratory analysis, the temperature-associated rise in nocturnal respiratory rate was significantly attenuated in the NY1301 + DDMP group (group × temperature interaction, p Conclusions: The primary outcome, subjective fatigue assessed using the web-based daily log, was not significantly different between groups during the summer study period.
Key Takeaways
- 01In an exploratory analysis, the temperature-associated rise in nocturnal respiratory rate was significantly attenuated in the NY1301 + DDMP group (group × temperature interaction, p Conclusions: The primary outcome, subjective fatigue assessed using the web-based daily log, was not significantly different between groups during the summer study period. [Tomizawa M (2026)]
- 02However, combined intake of NY1301 and DDMP was associated with shorter sleep onset latency, lower pre-task fatigue under standardized conditions, attenuation of the temperature-associated rise in nocturnal respiratory rate, and more pronounced post-stress autonomic recovery during the summer. [Tomizawa M (2026)]
- 03Objectives: Summer heat can impair sleep and contribute to autonomic dysregulation and fatigue-related symptoms. [Tomizawa M (2026)]
- 04Because heat exposure may induce oxidative stress and gut-related dysfunction, we hypothesized that combined intake of the probiotic Lacticaseibacillus paracasei subsp. [Tomizawa M (2026)]
The current Migaku evidence database contains 2 reusable source documents for Elderberry Sleep Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation.
- In an exploratory analysis, the temperature-associated rise in nocturnal respiratory rate was significantly attenuated in the NY1301 + DDMP group (group × temperature interaction, p Conclusions: The primary outcome, subjective fatigue assessed using the web-based daily log, was not significantly different between groups during the summer study period. [Tomizawa M (2026); evidence level 2]
- However, combined intake of NY1301 and DDMP was associated with shorter sleep onset latency, lower pre-task fatigue under standardized conditions, attenuation of the temperature-associated rise in nocturnal respiratory rate, and more pronounced post-stress autonomic recovery during the summer. [Tomizawa M (2026); evidence level 2]
- Objectives: Summer heat can impair sleep and contribute to autonomic dysregulation and fatigue-related symptoms. [Tomizawa M (2026); evidence level 2]
- Because heat exposure may induce oxidative stress and gut-related dysfunction, we hypothesized that combined intake of the probiotic Lacticaseibacillus paracasei subsp. [Tomizawa M (2026); evidence level 2]
- Results Results showed that energy drink group significantly improved repeated sprint performance and showed a potential to attenuate certain aspects of cognitive fatigue. [Liao LA (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources