What does the evidence say about Creatine Cognition Randomized Trial?

Updated May 2026

Quick Answer

Creatine Cognition Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Leg-press 1RM (k = 3; n = 111) improved with creatine: MD + 7.5 kg (95% CI + 2.2 to + 12.8; I² = 0%).

Key Takeaways

  • 01Leg-press 1RM (k = 3; n = 111) improved with creatine: MD + 7.5 kg (95% CI + 2.2 to + 12.8; I² = 0%). [Naddafha S (2026)]
  • 02Risk of bias was mostly "some concerns;" one large, preregistered, double-blind RCT was at low risk. [Naddafha S (2026)]
  • 03Conclusions In postmenopausal women, creatine, particularly ≥ 5 g·day⁻¹ with RT, yields small but meaningful gains in lean mass and strength without evidence of harm. [Naddafha S (2026)]
  • 04Background Menopause is accompanied by accelerated losses in muscle mass and strength and declining bone density. [Naddafha S (2026)]
The current Migaku evidence database contains 2 reusable source documents for Creatine Cognition Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Leg-press 1RM (k = 3; n = 111) improved with creatine: MD + 7.5 kg (95% CI + 2.2 to + 12.8; I² = 0%). [Naddafha S (2026); evidence level 1] - Risk of bias was mostly "some concerns;" one large, preregistered, double-blind RCT was at low risk. [Naddafha S (2026); evidence level 1] - Conclusions In postmenopausal women, creatine, particularly ≥ 5 g·day⁻¹ with RT, yields small but meaningful gains in lean mass and strength without evidence of harm. [Naddafha S (2026); evidence level 1] - Background Menopause is accompanied by accelerated losses in muscle mass and strength and declining bone density. [Naddafha S (2026); evidence level 1] - ABSTRACT NUMBER: ESOC2026OT29 EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON RECOVERY AFTER ISCHEMIC STROKE: THE SUCRE CLINICAL TRIAL [ABSTRACT NUMBER: ESOC2026OT29 EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON RECOVERY AFTER ISCHEMIC STROKE: THE SUCRE CLINICAL TRIAL (2026); evidence level 2] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Creatine monohydrate for lean mass, strength, and bone density in postmenopausal women: a systematic review and meta-analysis.
  2. ABSTRACT NUMBER: ESOC2026OT29 EFFECT OF CREATINE MONOHYDRATE SUPPLEMENTATION ON RECOVERY AFTER ISCHEMIC STROKE: THE SUCRE CLINICAL TRIAL