What does the evidence say about Chlorogenic Acid Cardiometabolic Randomized Trial?

Updated October 2026

Quick Answer

Chlorogenic Acid Cardiometabolic Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes.

Key Takeaways

  • 01Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. [Terzo S (2023)]
  • 02After six months of treatment Altilix® significantly reduced body weight, glycemic, and lipid parameters (total cholesterol, triglycerides, LDL-cholesterol) and improved hepatic functionality, CIMT, and FMD. [Terzo S (2023)]
  • 03In conclusion, these results confirm that Altilix® supplementation has a significant effect on cardiometabolic parameters not only in obese subjects but also in pre-obesity subjects. [Terzo S (2023)]
  • 04Our previous study demonstrated that a Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid and luteolin extracts, was able to improve several hepatic and cardio-metabolic parameters. [Terzo S (2023)]
The current Migaku evidence database contains 2 reusable source documents for Chlorogenic Acid Cardiometabolic Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Pre-obesity is a condition that predisposes to the risk of developing obesity, cardiovascular diseases (CVD), and diabetes. [Terzo S (2023); evidence level 2] - After six months of treatment Altilix® significantly reduced body weight, glycemic, and lipid parameters (total cholesterol, triglycerides, LDL-cholesterol) and improved hepatic functionality, CIMT, and FMD. [Terzo S (2023); evidence level 2] - In conclusion, these results confirm that Altilix® supplementation has a significant effect on cardiometabolic parameters not only in obese subjects but also in pre-obesity subjects. [Terzo S (2023); evidence level 2] - Our previous study demonstrated that a Cynara cardunculus (L.) based nutraceutical named Altilix® (Bionap, Italy), containing chlorogenic acid and luteolin extracts, was able to improve several hepatic and cardio-metabolic parameters. [Terzo S (2023); evidence level 2] - It also significantly improved thermotolerance and resistance to oxidative stress in C . [Todorova MN (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. A Nutraceutical Containing Chlorogenic Acid and Luteolin Improves Cardiometabolic Parameters in Subjects with Pre-Obesity: A 6-Month Randomized, Double-Blind, Placebo-Controlled Study.
  2. <i>Echinophora tenuifolia</i> L. subsp. <i>sibthorpiana</i> Modulates Stress Response and Mitochondrial Quality Under Glucose Stress in <i>Caenorhabditis elegans</i>.