# Vitamin K Fracture Risk Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/vitamin-k-fracture-risk-meta-analysis-evidence-review
Category: evidence-review
Summary: Vitamin K Fracture Risk Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are s
Last reviewed: 2026-08-06
Reviewed by: Migaku Evidence Review
# Vitamin K Fracture Risk Meta-analysis: What the Evidence Says

## Quick Answer

Vitamin K Fracture Risk Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis | systematic review | 1 | 2026-01-01 | 10.1136/bmj-2025-088050 |
| Polypharmacy and Bone Health in Patients with Type 2 Diabetes Mellitus: A Narrative Review | preclinical study | 4 | 2026-05-01 | 10.11005/jbm.25.975 |

## What The Sources Report

- Secondary outcomes included the risk of hip fracture, non-vertebral fracture, vertebral fracture, and falling, as well as the total number of falls. [Massé Olivier (2026); evidence level 1]
- If unpublished data, not obtained through personal communications, were found in another systematic review, we used that review to complete data extraction. [Massé Olivier (2026); evidence level 1]
- Fracture is a common complication of DM, especially those with longer diabetes duration, vascular complications, and due to the use of specific medications. BMD is a usual significant indicator of bone health and a primary predictor of fracture risk. [Kashmoola Israa O. (2026); evidence level 4]
- A low BMD means weaker bones and is often indicative of osteoporosis. Evidence stares that T2DM patients routinely reveal average or augmented BMD levels compared to those with type 1 DM (T1DM) or those without T2DM; nevertheless, they experience inappropriate risk of fractures. [Kashmoola Israa O. (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For vitamin K fracture risk meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Massé Olivier (2026). Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. DOI: 10.1136/bmj-2025-088050. PMCID: PMC13188451. PMID: 42161415. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13188451/
- Kashmoola Israa O. (2026). Polypharmacy and Bone Health in Patients with Type 2 Diabetes Mellitus: A Narrative Review. DOI: 10.11005/jbm.25.975. PMCID: PMC13284594. PMID: 42316445. License: https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Acces.... https://pmc.ncbi.nlm.nih.gov/articles/PMC13284594/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.