# Vitamin D Sleep Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/vitamin-d-sleep-meta-analysis-evidence-review
Category: evidence-review
Summary: Vitamin D Sleep Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systemati
Last reviewed: 2026-06-25
Reviewed by: Migaku Evidence Review
# Vitamin D Sleep Meta-analysis: What the Evidence Says

## Quick Answer

Vitamin D Sleep Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Vitamin D Deficiency Is Associated with a Higher 5-Year Risk of Obstructive Sleep Apnea and CPAP Use in Older Adults: An Anchor-Based Network Meta-Analysis. | systematic review | 1 | 2026-05-11 | 10.3390/medicina62050935 |
| Vitamin D as a Regulator of the Biological Clock—Implications for Circadian–Metabolic Dysregulation | narrative review | 3 | 2026-04-02 | 10.3390/ijms27073243 |

## What The Sources Report

- Therefore, the aim of this study was to investigate the association between vitamin D deficiency and the risk of patients receiving a diagnosis of OSA or utilizing CPAP, using the TriNetX research network to obtain real-world data. [Chiang JK (2026); evidence level 1]
- Materials and Methods: A retrospective cohort study using the TriNetX database was conducted to investigate the relationship between vitamin D deficiency and patients with risk of receiving an OSA diagnosis or patients treated with CPAP in older adults (≥65 years). [Chiang JK (2026); evidence level 1]
- Circadian misalignment has been unequivocally recognized as a risk factor for cardiometabolic diseases. [Vesković Milena (2026); evidence level 3]
- Inadequate sleep increases the risk of insulin resistance and metabolic syndrome; hence their co-appearance led to the designation of circadian syndrome. [Vesković Milena (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For vitamin d sleep meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Chiang JK (2026). Vitamin D Deficiency Is Associated with a Higher 5-Year Risk of Obstructive Sleep Apnea and CPAP Use in Older Adults: An Anchor-Based Network Meta-Analysis.. DOI: 10.3390/medicina62050935. PMCID: PMC13208848. PMID: 42195188. https://pmc.ncbi.nlm.nih.gov/articles/PMC13208848/
- Vesković Milena (2026). Vitamin D as a Regulator of the Biological Clock—Implications for Circadian–Metabolic Dysregulation. DOI: 10.3390/ijms27073243. PMCID: PMC13074111. PMID: 41977424. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13074111/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.