# Vitamin D Muscle Strength Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/vitamin-d-muscle-strength-meta-analysis-evidence-review
Category: evidence-review
Summary: Vitamin D Muscle Strength Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are
Last reviewed: 2026-05-26
Reviewed by: Migaku Evidence Review
# Vitamin D Muscle Strength Meta-analysis: What the Evidence Says

## Quick Answer

Vitamin D Muscle Strength Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 narrative review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials | narrative review | 3 | 2026-04-01 | 10.3803/EnM.2026.2938 |
| Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders | preclinical study | 4 | 2026-02-14 | 10.3390/nu18040629 |

## What The Sources Report

- Supported by this biological plausibility and by observational studies demonstrating a robust inverse association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of fractures and falls, the medical community has witnessed a global surge in vitamin D screening and empiric supplementation over the past two decades. [Kong Sung Hye (2026); evidence level 3]
- Furthermore, updated systematic reviews and meta-analyses published in 2025 have reinforced the conclusion that vitamin D supplementation does not reduce fall risk among community-dwelling older adults, with some analyses even suggesting potential harm at higher doses. [Kong Sung Hye (2026); evidence level 3]
- In contrast, rapid nongenomic signaling is mediated by membrane-associated VDR or by protein disulfide isomerases A3 (PDIA3), also known as membrane-associated, rapid response steroid-binding (MARRS). [Lee Ga Young (2026); evidence level 4]
- These pathways are closely associated with cellular metabolism, inflammatory regulation, and aging-related cellular dysfunction. [Lee Ga Young (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For vitamin d muscle strength meta-analysis, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Kong Sung Hye (2026). Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials. DOI: 10.3803/EnM.2026.2938. PMCID: PMC13172633. PMID: 42114835. License: https://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access.... https://pmc.ncbi.nlm.nih.gov/articles/PMC13172633/
- Lee Ga Young (2026). Vitamin D-Mediated Immunoregulation in Degenerative Diseases: Insights into Cardiovascular, Neurodegenerative and Musculoskeletal Disorders. DOI: 10.3390/nu18040629. PMCID: PMC12942877. PMID: 41754146. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12942877/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.