# Vitamin D Depression Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/vitamin-d-depression-meta-analysis-evidence-review
Category: evidence-review
Summary: Vitamin D Depression Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are syst
Last reviewed: 2026-05-26
Reviewed by: Migaku Evidence Review
# Vitamin D Depression Meta-analysis: What the Evidence Says

## Quick Answer

Vitamin D Depression Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose–response meta-analysis of randomized controlled trials | systematic review | 1 | 2026-03-17 | 10.3389/fnut.2026.1772451 |
| Vitamin D as a Regulator of the Biological Clock—Implications for Circadian–Metabolic Dysregulation | narrative review | 3 | 2026-04-02 | 10.3390/ijms27073243 |

## What The Sources Report

- Compared with antidepressant medications, vitamin D supplementation is generally considered well tolerated and is associated with a favorable safety profile. [Liu Hsuan-Hsien (2026); evidence level 1]
- By conducting a meta-analysis, we aimed to provide robust, quantitative evidence regarding the efficacy of vitamin D supplementation in mitigating depressive symptoms in this population. [Liu Hsuan-Hsien (2026); evidence level 1]
- Circadian misalignment has been unequivocally recognized as a risk factor for cardiometabolic diseases. [Vesković Milena (2026); evidence level 3]
- Inadequate sleep increases the risk of insulin resistance and metabolic syndrome; hence their co-appearance led to the designation of circadian syndrome. [Vesković Milena (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For vitamin d depression meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Liu Hsuan-Hsien (2026). Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose–response meta-analysis of randomized controlled trials. DOI: 10.3389/fnut.2026.1772451. PMCID: PMC13035762. PMID: 41923913. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13035762/
- Vesković Milena (2026). Vitamin D as a Regulator of the Biological Clock—Implications for Circadian–Metabolic Dysregulation. DOI: 10.3390/ijms27073243. PMCID: PMC13074111. PMID: 41977424. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13074111/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.