# Vitamin B6 PMS Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/vitamin-b6-pms-meta-analysis-evidence-review
Category: evidence-review
Summary: Vitamin B6 PMS Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic
Last reviewed: 2026-05-28
Reviewed by: Migaku Evidence Review
# Vitamin B6 PMS Meta-analysis: What the Evidence Says

## Quick Answer

Vitamin B6 PMS Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis | systematic review | 1 | 2025-09-02 | 10.1186/s12905-025-03991-x |
| Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications | preclinical study | 4 | 2026-01-31 | 10.3390/jcm15031124 |

## What The Sources Report

- It has been associated with reduced physical performance, diminish energy levels, and increased level of depression and anxiety. [Sharifipour Foruzan (2025); evidence level 1]
- Studies have explored the efficacy of vitamin B6 in managing pain associated with carpal tunnel syndrome, diabetic neuropathy, back pain, depression, and migraine headaches. [Sharifipour Foruzan (2025); evidence level 1]
- Some evidence suggests that women with Rh-negative blood type may have a higher likelihood of developing premenstrual symptoms, although mechanistic explanations remain speculative and findings are not yet consistent across studies. [Martire Francesco Giuseppe (2026); evidence level 4]
- High caffeine intake has also been linked to increased PMS risk, possibly through its impact on sleep quality, anxiety, and neuroendocrine regulation. [Martire Francesco Giuseppe (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For vitamin B6 PMS meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Sharifipour Foruzan (2025). The effectiveness of vitamin B6 in reducing mastalgia: a systematic review and meta-analysis. DOI: 10.1186/s12905-025-03991-x. PMCID: PMC12403960. PMID: 40898150. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is .... https://pmc.ncbi.nlm.nih.gov/articles/PMC12403960/
- Martire Francesco Giuseppe (2026). Premenstrual Syndrome and Nutritional Factors: A Narrative Review of Current Evidence and Clinical Implications. DOI: 10.3390/jcm15031124. PMCID: PMC12898590. PMID: 41682804. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12898590/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.