# Urolithin A Exercise Performance Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/urolithin-a-exercise-performance-randomized-trial-evidence-review
Category: evidence-review
Summary: Urolithin A Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this firs
Last reviewed: 2026-05-26
Reviewed by: Migaku Evidence Review
# Urolithin A Exercise Performance Randomized Trial: What the Evidence Says

## Quick Answer

Urolithin A Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 preclinical study, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review | preclinical study | 4 | 2026-04-05 | 10.3390/nu18071161 |
| Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners | research article | 4 | 2025-08-21 | 10.1007/s40279-025-02292-5 |

## What The Sources Report

- Individuals with sarcopenia face a significantly elevated risk of falls, fractures, cognitive impairment, and functional dependency, leading to increased hospitalization rates, prolonged lengths of stay, and greater healthcare costs. [Chin Hui San (2026); evidence level 4]
- These disruptions converge on key processes such as reduced neuromuscular integrity, impaired energy metabolism, and blunted anabolic signaling, ultimately contributing to declines in muscle strength and function. [Chin Hui San (2026); evidence level 4]
- Specifically, daily supplementation with 1000 mg UA for 4 months improved muscle resistance to fatigue, muscle strength, and maximal aerobic capacity by ~ 10%, leading to clinically meaningful improvements in a 6-min walk, a proxy for whole-body function and performance. [Whitfield Jamie (2025); evidence level 4]
- Levels of plasma acylcarnitines and C-reactive protein (CRP) were also reduced, suggesting UA exerts an anti-inflammatory effect. [Whitfield Jamie (2025); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For urolithin a exercise performance randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Chin Hui San (2026). Molecular Mechanisms and Nutritional Modulation in Sarcopenia: A Narrative Review. DOI: 10.3390/nu18071161. PMCID: PMC13074595. PMID: 41978211. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13074595/
- Whitfield Jamie (2025). Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners. DOI: 10.1007/s40279-025-02292-5. PMCID: PMC12628386. PMID: 40839339. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12628386/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.