# Tomato-lycopene-skin-health-randomized-trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/tomato-lycopene-skin-health-randomized-trial-evidence-review
Category: evidence-review
Summary: Tomato-lycopene-skin-health-randomized-trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pas
Last reviewed: 2026-08-15
Reviewed by: Migaku Evidence Review
# Tomato-lycopene-skin-health-randomized-trial: What the Evidence Says

## Quick Answer

Tomato-lycopene-skin-health-randomized-trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 narrative review, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Lycopene as Medicine: Unlocking the Therapeutic Power of a Bioactive Carotenoid | narrative review | 3 | 2026-05-05 | 10.1021/acsomega.6c01929 |
| Daily intake of a lycopene-rich juice is associated with reductions in inflammatory markers but not increases in skin carotenoids in a pilot study among participants with obesity | research article | 4 | 2025-12-19 | 10.1186/s40795-025-01222-y |

## What The Sources Report

- Together, these mechanisms highlight lycopene's
multifaceted bioactivity in maintaining health and reducing the risk
of noncommunicable diseases. [Hajareh Haghighi Farid (2026); evidence level 3]
- While high-density
lipoprotein (HDL) levels are not markedly increased, its functionality
improves through enhanced antioxidant capacity and reverse cholesterol
transport. [Hajareh Haghighi Farid (2026); evidence level 3]
- A diet rich in phytonutrients found in fruits and vegetables (FV) is critical for optimal health. [Jilcott Pitts Stephanie B. (2025); evidence level 4]
- Diets rich in carotenoids are linked with positive health outcomes, including reductions in the risk of cardiovascular disease and certain cancers. [Jilcott Pitts Stephanie B. (2025); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For tomato-lycopene-skin-health-randomized-trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Hajareh Haghighi Farid (2026). Lycopene as Medicine:
Unlocking the Therapeutic Power
of a Bioactive Carotenoid. DOI: 10.1021/acsomega.6c01929. PMCID: PMC13191698. PMID: 42179603. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13191698/
- Jilcott Pitts Stephanie B. (2025). Daily intake of a lycopene-rich juice is associated with reductions in inflammatory markers but not increases in skin carotenoids in a pilot study among participants with obesity. DOI: 10.1186/s40795-025-01222-y. PMCID: PMC12838468. PMID: 41420244. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is .... https://pmc.ncbi.nlm.nih.gov/articles/PMC12838468/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.