# Sam-e Mood Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/sam-e-mood-meta-analysis-evidence-review
Category: evidence-review
Summary: Sam-e Mood Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic rev
Last reviewed: 2026-07-04
Reviewed by: Migaku Evidence Review
# Sam-e Mood Meta-analysis: What the Evidence Says

## Quick Answer

Sam-e Mood Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| A Systematic Review and Meta-Analysis of EEG, fMRI, and fNIRS Studies on the Psychological Impact of Nature on Well-Being | systematic review | 1 | 2026-03-17 | 10.3390/ijerph23030377 |
| Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study | research article | 4 | 2026-01-01 | 10.2196/91819 |

## What The Sources Report

- For centuries, people of all cultures and disciplines have explored the relationship between nature and human well-being, with substantial evidence supporting nature's influence on psychological health. [Daube Alexandra (2026); evidence level 1]
- This interest has recognized that genetics alone cannot account for health risk factors, and that environmental exposure plays a substantial role in shaping brain health. [Daube Alexandra (2026); evidence level 1]
- When left untreated, youth anxiety is associated with poor academic functioning, social functioning, and well-being, and increased risk of depression, substance misuse, suicide attempts, and hospitalization in adulthood. [Yu Clare Tsz Kiu (2026); evidence level 4]
- Mindfulness-based interventions (MBIs), structured programs cultivating present-moment awareness with openness and nonjudgment, have emerged as a promising preventive approach, with evidence indicating moderate reductions in anxiety, and gains in emotional regulation, resilience, and coping among young people. [Yu Clare Tsz Kiu (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For sam-e mood meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Daube Alexandra (2026). A Systematic Review and Meta-Analysis of EEG, fMRI, and fNIRS Studies on the Psychological Impact of Nature on Well-Being. DOI: 10.3390/ijerph23030377. PMCID: PMC13026741. PMID: 41899754. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13026741/
- Yu Clare Tsz Kiu (2026). Using a Virtual Reality CAVE–Based Mindfulness Intervention to Promote Mental Well-Being in Adolescents With Anxiety Symptoms: Pre-Post Mixed Methods Pilot Study. DOI: 10.2196/91819. PMCID: PMC13263010. PMID: 42284594. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13263010/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.