# Saffron Pms Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/saffron-pms-randomized-trial-evidence-review
Category: evidence-review
Summary: Saffron Pms Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic
Last reviewed: 2026-07-29
Reviewed by: Migaku Evidence Review
# Saffron Pms Randomized Trial: What the Evidence Says

## Quick Answer

Saffron Pms Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 randomized trial.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysis | systematic review | 1 | 2026-01-01 | 10.4082/kjfm.24.0259 |
| Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff | randomized trial | 2 | 2025-10-21 | 10.1186/s40780-025-00495-6 |

## What The Sources Report

- A Swiss study found that 10% of participants experienced PMS, whereas 3% experienced PMDD. [Mohammadi Mohammad Mehdi (2026); evidence level 1]
- These challenges include legal issues, suicidal ideation, reduced work productivity, social isolation, parenting difficulties, increased absenteeism, disruptions of personal and social relationships, and frequent hospital visits. [Mohammadi Mohammad Mehdi (2026); evidence level 1]
- Women with PMS often experience diminished work productivity, increased absenteeism, and reduced participation in leisure activities and social engagements. [Saghafi Fatemeh (2025); evidence level 2]
- Emerging evidence also indicates that chronic inflammation and oxidative stress may play a role in PMS development. [Saghafi Fatemeh (2025); evidence level 2]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. There is trial evidence in the current set, but population and intervention details still matter. For saffron pms randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Mohammadi Mohammad Mehdi (2026). Effect of saffron on premenstrual syndrome and dysmenorrhea: a systematic review and meta-analysis. DOI: 10.4082/kjfm.24.0259. PMCID: PMC12835668. PMID: 41151539. License: https://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access.... https://pmc.ncbi.nlm.nih.gov/articles/PMC12835668/
- Saghafi Fatemeh (2025). Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff. DOI: 10.1186/s40780-025-00495-6. PMCID: PMC12538989. PMID: 41121435. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12538989/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.