# Pterostilbene Sleep Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/pterostilbene-sleep-randomized-trial-evidence-review
Category: evidence-review
Summary: Pterostilbene Sleep Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are ra
Last reviewed: 2026-08-16
Reviewed by: Migaku Evidence Review
# Pterostilbene Sleep Randomized Trial: What the Evidence Says

## Quick Answer

Pterostilbene Sleep Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 randomized trial, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial | randomized trial | 2 | 2026-05-13 | 10.3389/fragi.2026.1773667 |
| Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review | preclinical study | 4 | 2026-04-23 | 10.3390/ijms27093749 |

## What The Sources Report

- The deficiency of E2 in post-menopausal women can lead to osteoporosis, increased risk of cardiovascular disease and increased risk of type 2 diabetes. [Holmes Holly E. (2026); evidence level 2]
- Hot flashes are associated with discomfort, poor sleep, fatigue and a decreased quality of life. [Holmes Holly E. (2026); evidence level 2]
- Wukich and colleagues established that diabetes adversely affects outcomes across all orthopedic subspecialties, including increased surgical site infections, delayed wound healing, and impaired bone consolidation. [Santos Márcia da Silva (2026); evidence level 4]
- Meta-analytic evidence demonstrates that diabetic patients have an odds ratio of 2.11 for impaired fracture healing compared to non-diabetic individuals, while tendinopathy prevalence is markedly elevated, with 27.5% of diabetic patients experiencing shoulder disorders compared to 5% in the general population. [Santos Márcia da Silva (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For pterostilbene sleep randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Holmes Holly E. (2026). Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial. DOI: 10.3389/fragi.2026.1773667. PMCID: PMC13213337. PMID: 42211736. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13213337/
- Santos Márcia da Silva (2026). Nutritional Interventions to Optimize Orthobiologic Therapy Quality in Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Framework: A Narrative Review. DOI: 10.3390/ijms27093749. PMCID: PMC13164227. PMID: 42123336. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13164227/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.