# Niacinamide Skin Hydration Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/niacinamide-skin-hydration-randomized-trial-evidence-review
Category: evidence-review
Summary: Niacinamide Skin Hydration Randomized Trial has 1 source documents in the current Migaku evidence database. The strongest available sources in this first pass
Last reviewed: 2026-08-20
Reviewed by: Migaku Evidence Review
# Niacinamide Skin Hydration Randomized Trial: What the Evidence Says

## Quick Answer

Niacinamide Skin Hydration Randomized Trial has 1 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 randomized trial.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial | randomized trial | 2 | 2026-05-10 | 10.1111/jocd.70898 |

## What The Sources Report

- Its pathophysiology involves a deficiency in essential stratum corneum lipids such as ceramides, cholesterol, and free fatty acids, together with reduced levels of natural moisturizing factors (NMFs) and increased TEWL. [Morgado‐Carrasco Daniel (2026); evidence level 2]
- While conventional management typically relies on basic emollients and cutaneous hydration, there is a growing need for multi-active formulations that facilitate functional barrier enhancement and address associated symptoms such as pruritus. [Morgado‐Carrasco Daniel (2026); evidence level 2]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For niacinamide skin hydration randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Morgado‐Carrasco Daniel (2026). Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28‐Day Randomized, Split‐Leg, Untreated‐Controlled Trial. DOI: 10.1111/jocd.70898. PMCID: PMC13158435. PMID: 42108609. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13158435/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.