# Melissa Sleep Quality Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/melissa-sleep-quality-randomized-trial-evidence-review
Category: evidence-review
Summary: Melissa Sleep Quality Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are 
Last reviewed: 2026-07-07
Reviewed by: Migaku Evidence Review
# Melissa Sleep Quality Randomized Trial: What the Evidence Says

## Quick Answer

Melissa Sleep Quality Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 research article, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation | research article | 4 | 2026-05-13 | 10.29219/fnr.v70.14023 |
| Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies | preclinical study | 4 | 2026-02-19 | 10.3390/plants15040650 |

## What The Sources Report

- Elevated or blunted cortisol levels have been associated with impaired sleep quality, heightened emotional distress, and reduced mental well-being in both clinical populations and non-clinical models (,,). [Mazzola Giuseppe (2026); evidence level 4]
- Experimental models suggest that rosmarinic acid, the main bioactive compound of, can reduce stress-induced corticosterone elevations, which may translate into improved sleep architecture and psychological outcomes. [Mazzola Giuseppe (2026); evidence level 4]
- Historical use of medicinal plants was a result of cumulative trial and error experience and the transmission of traditional knowledge between generations, which later inspired systematic efforts to turn empirical claims into evidence-based arguments. [Cîmpeanu Ioan-Alexandru (2026); evidence level 4]
- Also, standardization and phytochemical reporting is the preferred method for interpreting the evidence base across Lamiaceae, as its composition is influenced by genetics, geography, cultivation, and post-harvest handling. [Cîmpeanu Ioan-Alexandru (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For melissa sleep quality randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Mazzola Giuseppe (2026). Salivary cortisol dynamics and their relationship with sleep and mental well-being in adults receiving a phospholipid-based Melissa officinalis supplement: a secondary analysis in a subpopulation. DOI: 10.29219/fnr.v70.14023. PMCID: PMC13224935. PMID: 42232738. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13224935/
- Cîmpeanu Ioan-Alexandru (2026). Melissa officinalis L. (Lemon Balm): An Integrative Review of Phytochemistry and Evidence from Preclinical Research to Clinical Studies. DOI: 10.3390/plants15040650. PMCID: PMC12944213. PMID: 41754356. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12944213/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.