# Melissa Sleep Quality Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/melissa-sleep-quality-meta-analysis-evidence-review
Category: evidence-review
Summary: Melissa Sleep Quality Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mix
Last reviewed: 2026-07-07
Reviewed by: Migaku Evidence Review
# Melissa Sleep Quality Meta-analysis: What the Evidence Says

## Quick Answer

Melissa Sleep Quality Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 preclinical study, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors | preclinical study | 4 | 2026-05-22 | 10.3390/nu18111666 |
| Melissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress | research article | 4 | 2026-01-31 | 10.29219/fnr.v70.13729 |

## What The Sources Report

- Chronic sleep disturbances are increasingly recognized as significant risk factors for a range of health conditions, including cardiovascular disease, diabetes, obesity, depression, and neurodegenerative disorders such as Alzheimer's disease. [Jee Hye Jin (2026); evidence level 4]
- These findings underscore the significant public health impact of insomnia and highlight the need for therapeutic strategies with improved safety profiles and well-defined mechanisms of action. [Jee Hye Jin (2026); evidence level 4]
- Conversely, evidence suggests thatmay exert rapid central effects, independently of sleep, through modulation of neurotransmitters and stress-related neuroendocrine pathways (,,). [Rondanelli Mariangela (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For melissa sleep quality meta-analysis, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Jee Hye Jin (2026). Hypnotic Effects of Hypericum perforatum L. and Melissa officinalis L. Through Adenosine and Melatonin Receptors. DOI: 10.3390/nu18111666. PMCID: PMC13258432. PMID: 42280309. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13258432/
- Rondanelli Mariangela (2026). Melissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress. DOI: 10.29219/fnr.v70.13729. PMCID: PMC12952214. PMID: 41777239. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12952214/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.