# Maca Stress Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/maca-stress-randomized-trial-evidence-review
Category: evidence-review
Summary: Maca Stress Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic
Last reviewed: 2026-06-23
Reviewed by: Migaku Evidence Review
# Maca Stress Randomized Trial: What the Evidence Says

## Quick Answer

Maca Stress Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials | systematic review | 1 | 2026-01-01 | 10.1016/j.jtcme.2025.11.001 |
| Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy | preclinical study | 4 | 2026-04-18 | 10.3390/ijms27083607 |

## What The Sources Report

- In general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate. [Ho Chao-Yen (2026); evidence level 1]
- The analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls. [Ho Chao-Yen (2026); evidence level 1]
- Under normal conditions, it is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for degradation. [Cipriano Giovanni Luca (2026); evidence level 4]
- The following subsections provide a detailed analysis of the molecular profiles and clinical evidence for these three primary bioactives. [Cipriano Giovanni Luca (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For maca stress randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Ho Chao-Yen (2026). Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials. DOI: 10.1016/j.jtcme.2025.11.001. PMCID: PMC12902307. PMID: 41696741. License: https://creativecommons.org/licenses/by-nc-nd/4.0/. https://pmc.ncbi.nlm.nih.gov/articles/PMC12902307/
- Cipriano Giovanni Luca (2026). Phytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy. DOI: 10.3390/ijms27083607. PMCID: PMC13116414. PMID: 42074246. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13116414/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.