# Maca Fatigue Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/maca-fatigue-randomized-trial-evidence-review
Category: evidence-review
Summary: Maca Fatigue Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systemati
Last reviewed: 2026-06-03
Reviewed by: Migaku Evidence Review
# Maca Fatigue Randomized Trial: What the Evidence Says

## Quick Answer

Maca Fatigue Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials | systematic review | 1 | 2026-01-01 | 10.1016/j.jtcme.2025.11.001 |
| Management of Antidepressant-Induced Sexual Dysfunction: A Literature Review | preclinical study | 4 | 2025-08-15 | 10.7759/cureus.90170 |

## What The Sources Report

- In general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate. [Ho Chao-Yen (2026); evidence level 1]
- The analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls. [Ho Chao-Yen (2026); evidence level 1]
- While depression itself is often associated with sexual dysfunction (typically in the form of decreased libido), the use of an antidepressant may ironically exacerbate this by causing more sexual dysfunction (typically in difficulty with arousal and anorgasmia). [Muacevic Alexander (2025); evidence level 4]
- Sexual problems (such as impotence, ejaculatory dysfunction, dyspareunia, vaginismus, anorgasmia) were found in 26-31.8% of normal subjects, 45% of non-treated depressed patients, and 62-63% of treated depressed patients. [Muacevic Alexander (2025); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For maca fatigue randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Ho Chao-Yen (2026). Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials. DOI: 10.1016/j.jtcme.2025.11.001. PMCID: PMC12902307. PMID: 41696741. License: https://creativecommons.org/licenses/by-nc-nd/4.0/. https://pmc.ncbi.nlm.nih.gov/articles/PMC12902307/
- Muacevic Alexander (2025). Management of Antidepressant-Induced Sexual Dysfunction: A Literature Review. DOI: 10.7759/cureus.90170. PMCID: PMC12433685. PMID: 40955264. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12433685/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.