# Lion's Mane Cognition Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/lion-s-mane-cognition-randomized-trial-evidence-review
Category: evidence-review
Summary: Lion's Mane Cognition Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are 
Last reviewed: 2026-05-21
Reviewed by: Migaku Evidence Review
# Lion's Mane Cognition Randomized Trial: What the Evidence Says

## Quick Answer

Lion's Mane Cognition Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 randomized trial, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study | randomized trial | 2 | 2025-04-10 | 10.3389/fnut.2025.1405796 |
| Air pollution and Alzheimer's disease prevention: The science and a prevention plan | narrative review | 3 | 2025-10-24 | 10.1177/13872877251386482 |

## What The Sources Report

- Another murine study found thatincreased levels of serotonin, dopamine, and noradrenaline, neurotransmitters that are often decreased in depression. [Surendran Geyan (2025); evidence level 2]
- The theory that AD may start many decades before symptoms develop should now be adjusted to include the new reality that AD may, in fact, begin in childhood in the many highly polluted areas of the globe, which essentially puts hundreds of millions more people at increased risk. [Khalsa Dharma Singh (2025); evidence level 3]
- Secondly, a plan to prevent pathological changes and reduce the risk of AD and other neurodegenerative disorders will be presented. [Khalsa Dharma Singh (2025); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For lion's mane cognition randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Surendran Geyan (2025). Acute effects of a standardised extract of Hericium erinaceus (Lion’s Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study. DOI: 10.3389/fnut.2025.1405796. PMCID: PMC12018234. PMID: 40276537. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12018234/
- Khalsa Dharma Singh (2025). Air pollution and Alzheimer's disease prevention: The science and a prevention plan. DOI: 10.1177/13872877251386482. PMCID: PMC12647382. PMID: 41134977. License: https://creativecommons.org/licenses/by-nc/4.0/ https://creativecommons.org/licenses/by-nc/4.0/ https://us.sagepub.co.... https://pmc.ncbi.nlm.nih.gov/articles/PMC12647382/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.