# Lactoferrin Supplementation Acne Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/lactoferrin-supplementation-acne-meta-analysis-evidence-review
Category: evidence-review
Summary: Lactoferrin Supplementation Acne Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first p
Last reviewed: 2026-06-23
Reviewed by: Migaku Evidence Review
# Lactoferrin Supplementation Acne Meta-analysis: What the Evidence Says

## Quick Answer

Lactoferrin Supplementation Acne Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review | systematic review | 1 | 2026-02-17 | 10.1007/s13555-026-01659-4 |
| The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health. | preclinical study | 4 | 2026-05-15 | 10.3390/ijms27104451 |

## What The Sources Report

- Cutibacterium acnes Propionibacterium acnes 6 7 The pathogenesis of acne is multifactorial, arising from the interplay of increased sebum production, abnormal follicular keratinization, colonization with(formerly), and inflammation with contributions from genetic, hormonal, and environmental factors. [Warp Peyton V. (2026); evidence level 1]
- Limited studies of gut microbiota in patients with acne have identified overall reduced diversity, a higher Bacteroidetes:Firmicutes ratio, enrichment of Proteobacteria, depletion of Actinobacteria, and loss of beneficial genera, includingand. [Warp Peyton V. (2026); evidence level 1]
- We link mechanistic insights with clinical and preclinical evidence and uniquely map molecular functions to dermatologic and trichologic outcomes. [Kaplan N (2026); evidence level 4]
- Lactoferrin is a naturally occurring bioactive glycoprotein that is part of the body's innate immune system and has essential roles in iron metabolism, microbial defense, inflammation regulation, and tissue repair. [Kaplan N (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For lactoferrin supplementation acne meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Warp Peyton V. (2026). Prebiotics, Probiotics, and Postbiotics for Acne Vulgaris: A Systematic Review. DOI: 10.1007/s13555-026-01659-4. PMCID: PMC13013907. PMID: 41703218. License: https://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/ This article is licens.... https://pmc.ncbi.nlm.nih.gov/articles/PMC13013907/
- Kaplan N (2026). The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health.. DOI: 10.3390/ijms27104451. PMCID: PMC13207968. PMID: 42196429. https://pmc.ncbi.nlm.nih.gov/articles/PMC13207968/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.