# Lactoferrin Immune Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/lactoferrin-immune-meta-analysis-evidence-review
Category: evidence-review
Summary: Lactoferrin Immune Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed 
Last reviewed: 2026-07-05
Reviewed by: Migaku Evidence Review
# Lactoferrin Immune Meta-analysis: What the Evidence Says

## Quick Answer

Lactoferrin Immune Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 preclinical study, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health | preclinical study | 4 | 2026-05-15 | 10.3390/ijms27104451 |
| Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker | research article | 4 | 2026-01-01 | 10.3892/mi.2026.307 |

## What The Sources Report

- These peptides have been associated with immune regulation, anti-inflammatory, and antimicrobial properties, possibly modulating the gut microbiome and exhibiting systemic activity to mitigate microbial infections. [Kaplan Nicole (2026); evidence level 4]
- In a clinical study, lactoferrin supplementation has been linked to a pronounced increase in circulating neutrophil precursors, and an associated reduction in TNF-α and IL-6 production. [Kaplan Nicole (2026); evidence level 4]
- Lactoferrin is found in various body fluids including saliva, dental plaque, GCF, digestive secretions, bronchial secretions, bile, urine, breast milk, serum and tears. [Patil Gauri Vilas (2026); evidence level 4]
- Lactoferrin concentrations have been reported to be increased in stimulated whole saliva of individuals with chronic periodontitis and are positively associated with a probing pocket depth (PPD) of ≥6 mm. [Patil Gauri Vilas (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For lactoferrin immune meta-analysis, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Kaplan Nicole (2026). The Protective and Regenerative Potential of Lactoferrin in Hair and Skin Health. DOI: 10.3390/ijms27104451. PMCID: PMC13207968. PMID: 42196429. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13207968/
- Patil Gauri Vilas (2026). Role of lactoferrin in periodontal disease: A meta-analytical assessment of its reliability as a biomarker. DOI: 10.3892/mi.2026.307. PMCID: PMC12997025. PMID: 41859028. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12997025/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.