# L-citrulline Blood Pressure Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/l-citrulline-blood-pressure-meta-analysis-evidence-review
Category: evidence-review
Summary: L-citrulline Blood Pressure Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass a
Last reviewed: 2026-06-24
Reviewed by: Migaku Evidence Review
# L-citrulline Blood Pressure Meta-analysis: What the Evidence Says

## Quick Answer

L-citrulline Blood Pressure Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials | systematic review | 1 | 2026-03-06 | 10.1002/fsn3.71603 |
| Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction. | research article | 4 | 2026-03-18 | 10.1038/s41598-026-43958-y |

## What The Sources Report

- More importantly, this BP elevation was closely associated with adverse outcomes, with cardiovascular mortality risk increasing by 21% for every 10 mmHg increase in SBP, and winter cardiovascular mortality rates being 41% higher than those in summer (Yang et al. ). [Luo Ping (2026); evidence level 1]
- Given that cold environment-induced BP elevation is one of the important modifiable risk factors for CVD (Gu et al. ; Yokoyama et al. ), targeted interventions to control elevated BP during cold weather are particularly crucial (Xu et al. ,). [Luo Ping (2026); evidence level 1]
- Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction. [van Kammen C (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For L-citrulline blood pressure meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Luo Ping (2026). Effect of L‐Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. DOI: 10.1002/fsn3.71603. PMCID: PMC12965904. PMID: 41797970. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12965904/
- van Kammen C (2026). Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction.. DOI: 10.1038/s41598-026-43958-y. PMCID: PMC13133094. PMID: 41844935. https://pmc.ncbi.nlm.nih.gov/articles/PMC13133094/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.