# L-citrulline Blood Pressure Cold Environments Meta-analysis: What the Evidence Says
Canonical: https://www.migaku.app/guides/l-citrulline-blood-pressure-cold-environments-meta-analysis-evidence-review
Category: evidence-review
Summary: L-citrulline Blood Pressure Cold Environments Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in
Last reviewed: 2026-06-26
Reviewed by: Migaku Evidence Review
# L-citrulline Blood Pressure Cold Environments Meta-analysis: What the Evidence Says

## Quick Answer

L-citrulline Blood Pressure Cold Environments Meta-analysis has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. | systematic review | 1 | 2026-03-06 | 10.1002/fsn3.71603 |
| Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives | narrative review | 3 | 2026-01-09 | 10.3390/ijms27020692 |

## What The Sources Report

- The primary objective of this systematic review and meta-analysis is to investigate whether L-citrulline supplementation can counteract the adverse effects of cold environments on individual blood pressure (BP), providing scientific evidence for the clinical development and application of L-citrulline as a cardiovascular protective nutritional supplement. [Luo P (2026); evidence level 1]
- The Cochrane Risk of Bias tool and JADAD scoring scale were used to assess risk of bias and literature quality of the included randomized controlled trials (RCTs). [Luo P (2026); evidence level 1]
- While a gradual decline in testosterone with advancing age is well recognized-most notably in men aged 70-80 years, and progressively in women during the premenopausal period with a stabilization or a modest increase after menopause -cumulative evidence has documented an additional, age-independent decline in men. [Fraile-Martínez Óscar (2026); evidence level 3]
- From a medical perspective, low testosterone levels (clinically diagnosed as hypogonadism) are strongly associated with various chronic maladies including metabolic syndrome, cardiovascular disease and overall mortality. [Fraile-Martínez Óscar (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For l-citrulline blood pressure cold environments meta-analysis, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Luo P (2026). Effect of L-Citrulline Intake on Blood Pressure in Cold Environments: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.. DOI: 10.1002/fsn3.71603. PMCID: PMC12965904. PMID: 41797970. https://pmc.ncbi.nlm.nih.gov/articles/PMC12965904/
- Fraile-Martínez Óscar (2026). Understanding the Secular Decline in Testosterone: Mechanisms, Consequences, and Clinical Perspectives. DOI: 10.3390/ijms27020692. PMCID: PMC12841019. PMID: 41596342. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12841019/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.