# L-arginine Exercise Performance Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/l-arginine-exercise-performance-randomized-trial-evidence-review
Category: evidence-review
Summary: L-arginine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first
Last reviewed: 2026-06-06
Reviewed by: Migaku Evidence Review
# L-arginine Exercise Performance Randomized Trial: What the Evidence Says

## Quick Answer

L-arginine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 preclinical study, 1 research article.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Targeting muscle–vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention | preclinical study | 4 | 2026-04-02 | 10.3389/fnut.2025.1739173 |
| Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes | research article | 4 | 2026-03-25 | 10.3389/fnut.2026.1788549 |

## What The Sources Report

- Within this framework, integrative approaches that combine nutritional and exercise interventions have garnered significant scholarly attention as pivotal strategies to mitigate age-associated declines in both muscular and vascular functionalities. [Lin Xinyi (2026); evidence level 4]
- Therefore, leucine represents the BCAA with the most compelling mechanistic and clinical evidence relevant to muscle-vascular interactions and healthy aging, justifying its emphasis in the present review. [Lin Xinyi (2026); evidence level 4]
- Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,-). [Uçar Halil (2026); evidence level 4]
- However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For l-arginine exercise performance randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Lin Xinyi (2026). Targeting muscle–vasculature crosstalk in aging through the integrative roles of L-citrulline, leucine, and exercise: focus on muscle metabolism, vascular function, and sarcopenia prevention. DOI: 10.3389/fnut.2025.1739173. PMCID: PMC13083166. PMID: 42005822. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13083166/
- Uçar Halil (2026). Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes. DOI: 10.3389/fnut.2026.1788549. PMCID: PMC13057471. PMID: 41958907. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13057471/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.