# Holy Basil Anxiety Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/holy-basil-anxiety-randomized-trial-evidence-review
Category: evidence-review
Summary: Holy Basil Anxiety Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are ran
Last reviewed: 2026-07-04
Reviewed by: Migaku Evidence Review
# Holy Basil Anxiety Randomized Trial: What the Evidence Says

## Quick Answer

Holy Basil Anxiety Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 2 randomized trial.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study | randomized trial | 2 | 2026-02-09 | 10.1186/s13063-026-09495-9 |
| Basil ( Ocimum basilicum ) to Alleviate Anxiety in Patients With Major Depressive Disorder: A Randomized Placebo‐Controlled Clinical Trial | randomized trial | 2 | 2025-11-14 | 10.1002/brb3.70994 |

## What The Sources Report

- It was concluded that the mechanism of action of adaptogens is associated with the regulation of the HPA axis, leading to reduced levels of cortisol and subsequently modulating the key mediator of stress response. [McKinney Erin (2026); evidence level 2]
- The change in sleep duration and sleep disturbances score reduced; however, it did not show statistical significance compared to placebo, as participants with intrinsic sleep problems were excluded from the study. [McKinney Erin (2026); evidence level 2]
- Depression can affect thoughts, mood, and physical health and can be associated with numerous symptoms such as low mood, fatigue, sadness, insomnia, anhedonia, and cognitive impairment symptoms (Li et al.; Schulz and Arora). [Talaei Mahva (2025); evidence level 2]
- Anxiety disorders are the most common associated disorders in depressed patients. [Talaei Mahva (2025); evidence level 2]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is trial evidence in the current set, but population and intervention details still matter. For holy basil anxiety randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- McKinney Erin (2026). Effects of multi-herb and ashwagandha root formulas on stress modulation: a randomized, double-blind, placebo-controlled clinical study. DOI: 10.1186/s13063-026-09495-9. PMCID: PMC12983611. PMID: 41656269. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is .... https://pmc.ncbi.nlm.nih.gov/articles/PMC12983611/
- Talaei Mahva (2025). Basil ( Ocimum basilicum ) to Alleviate Anxiety in Patients With Major Depressive Disorder: A Randomized Placebo‐Controlled Clinical Trial. DOI: 10.1002/brb3.70994. PMCID: PMC12617443. PMID: 41236933. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12617443/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.