# Grape-seed-extract-visual-performance-randomized-trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/grape-seed-extract-visual-performance-randomized-trial-evidence-review
Category: evidence-review
Summary: Grape-seed-extract-visual-performance-randomized-trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this
Last reviewed: 2026-08-16
Reviewed by: Migaku Evidence Review
# Grape-seed-extract-visual-performance-randomized-trial: What the Evidence Says

## Quick Answer

Grape-seed-extract-visual-performance-randomized-trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, randomized trial, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 randomized trial.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Grapes and their by-products effects on growth performance, intestinal histomorphology, immune response and antioxidant status in broiler chickens – A meta-analysis | systematic review | 1 | 2026-06-01 | 10.1016/j.psj.2026.106814 |
| Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial | randomized trial | 2 | 2025-01-01 | 10.4103/jrms.jrms_742_25 |

## What The Sources Report

- Genetic selection has been accompanied by optimized feed and improved health care, all of which have been combined to make broiler production more resource efficient. [Riaz Roshan (2026); evidence level 1]
- The authorized banning of antibiotics in feed formulas in several main markets has rapidly increased the quest for natural substitutes that will provide similar growth output, growth performance, immune competence, and feed efficiency. [Riaz Roshan (2026); evidence level 1]
- Migraine symptoms have a negative impact on the patients' quality of life. 2 3 4 5 6 Although the physiopathology of migraine is not fully understood, evidence suggests that mitochondrial dysfunction followed by elevated levels of reactive oxygen species plays an important role in migraine pain. [Eshaghian Niloofar (2025); evidence level 2]
- Accordingly, previous studies have shown higher levels of oxidative stress in migraine patients than healthy individuals. In addition to oxidative stress, migraine is associated with high levels of inflammatory biomarkers such as calcitonin gene-related peptide (CGRP). [Eshaghian Niloofar (2025); evidence level 2]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. There is trial evidence in the current set, but population and intervention details still matter. For grape-seed-extract-visual-performance-randomized-trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Riaz Roshan (2026). Grapes and their by-products effects on growth performance, intestinal histomorphology, immune response and antioxidant status in broiler chickens – A meta-analysis. DOI: 10.1016/j.psj.2026.106814. PMCID: PMC13053995. PMID: 41887174. License: https://creativecommons.org/licenses/by-nc-nd/4.0/. https://pmc.ncbi.nlm.nih.gov/articles/PMC13053995/
- Eshaghian Niloofar (2025). Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial. DOI: 10.4103/jrms.jrms_742_25. PMCID: PMC12860465. PMID: 41623439. License: https://creativecommons.org/licenses/by-nc-nd/4.0/. https://pmc.ncbi.nlm.nih.gov/articles/PMC12860465/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.