# Ergothioneine Fatigue Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/ergothioneine-fatigue-randomized-trial-evidence-review
Category: evidence-review
Summary: Ergothioneine Fatigue Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are 
Last reviewed: 2026-06-26
Reviewed by: Migaku Evidence Review
# Ergothioneine Fatigue Randomized Trial: What the Evidence Says

## Quick Answer

Ergothioneine Fatigue Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 2 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans—A Narrative Review | preclinical study | 4 | 2026-02-27 | PMC12986667 |
| Anserine, Balenine, and Ergothioneine: Impact of Histidine-Containing Compounds on Exercise Performance—A Narrative Review | preclinical study | 4 | 2025-02-27 | 10.3390/nu17050828 |

## What The Sources Report

- Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans—A Narrative Review [Jędrejko M (2026); evidence level 4]
- A particularly high content, 109 mg/kg, is found in dried flakes of Bonito tuna (Katsuwonus pelamis). [Jędrejko Maciej (2025); evidence level 4]
- Slightly lower levels of histidine can be found in vegetable protein sources, such as beans, peas, and soybeans. [Jędrejko Maciej (2025); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For ergothioneine fatigue randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Jędrejko M (2026). Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans—A Narrative Review. PMCID: PMC12986667. https://pmc.ncbi.nlm.nih.gov/articles/PMC12986667/
- Jędrejko Maciej (2025). Anserine, Balenine, and Ergothioneine: Impact of Histidine-Containing Compounds on Exercise Performance—A Narrative Review. DOI: 10.3390/nu17050828. PMCID: PMC11901597. PMID: 40077698. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC11901597/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.