# Ergothioneine Exercise Performance Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/ergothioneine-exercise-performance-randomized-trial-evidence-review
Category: evidence-review
Summary: Ergothioneine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this fi
Last reviewed: 2026-08-17
Reviewed by: Migaku Evidence Review
# Ergothioneine Exercise Performance Randomized Trial: What the Evidence Says

## Quick Answer

Ergothioneine Exercise Performance Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are mixed biomedical and public-health sources, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 research article, 1 preclinical study.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans | research article | 4 | 2026-03-05 | 10.1186/s12967-026-07937-1 |
| Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans—A Narrative Review | preclinical study | 4 | 2026-02-27 | 10.3390/nu18050781 |

## What The Sources Report

- At the metabolic level, HIIT is often associated with greater engagement of glycolytic pathways, accompanied by pronounced lactate accumulation and marked perturbations in central carbon and amino-acid metabolism. [Liu Jianxiu (2026); evidence level 4]
- By contrast, MICT promotes more sustained aerobic metabolism and higher rates of fatty acid oxidation, while LIT can still induce favourable changes in substrate utilization and cardiometabolic risk markers, particularly when performed regularly over time. [Liu Jianxiu (2026); evidence level 4]
- Contemporary recommendations regarding performance-enhancing nutritional strategies are now based on evidence-informed guidelines developed by leading sports organizations, including the International Olympic Committee, the International Society of Sports Nutrition, and the Australian Institute of Sport. [Jędrejko Maciej (2026); evidence level 4]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

For ergothioneine exercise performance randomized trial, the current source set is useful for orientation, but it is not yet broad enough for strong claims. Use cautious language and keep conclusions close to the cited sources.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Liu Jianxiu (2026). Metabolomic profiling of intensity-dependent responses to acute exercise in healthy humans. DOI: 10.1186/s12967-026-07937-1. PMCID: PMC13072661. PMID: 41787548. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ This article is .... https://pmc.ncbi.nlm.nih.gov/articles/PMC13072661/
- Jędrejko Maciej (2026). Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans—A Narrative Review. DOI: 10.3390/nu18050781. PMCID: PMC12986667. PMID: 41829950. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC12986667/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.