# Creatine Working Memory Randomized Trial: What the Evidence Says
Canonical: https://www.migaku.app/guides/creatine-working-memory-randomized-trial-evidence-review
Category: evidence-review
Summary: Creatine Working Memory Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass ar
Last reviewed: 2026-07-09
Reviewed by: Migaku Evidence Review
# Creatine Working Memory Randomized Trial: What the Evidence Says

## Quick Answer

Creatine Working Memory Randomized Trial has 2 source documents in the current Migaku evidence database. The strongest available sources in this first pass are systematic review, so conclusions should be framed as evidence-aware guidance rather than medical advice.

## Key Takeaways

- This page is generated only from sources stored in the Migaku evidence knowledge base.
- Current evidence mix: 1 systematic review, 1 narrative review.
- Claims should be interpreted with the source type, study design, population, and publication date in mind.
- This article is educational and does not replace care from a qualified clinician.

## Evidence Map

| Source | Evidence type | Level | Date | Identifier |
| --- | --- | ---: | --- | --- |
| Creatine and Cognition in Aging: A Systematic Review of Evidence in Older Adults | systematic review | 1 | 2026-02-01 | 10.1093/nutrit/nuaf135 |
| Creatine: Clinical Implications for Orthopedic Surgeons | narrative review | 3 | 2026-02-19 | 10.7759/cureus.103937 |

## What The Sources Report

- The proportion of the world's population over 60 years is projected to double from 12% to 22% by 2050.Aging is known to be associated with various declines in physical and cognitive function. [Marshall Samantha (2026); evidence level 1]
- ,,,, Previous research has shown that dietary creatine supplementation is associated with a reduction in the effects of aging on muscle and bone in older adults, especially when combined with RT.Although there has been extensive research on creatine's effects on physical function in both healthy and clinical populations,the impact of creatine on cognition and brain health remains less well established. [Marshall Samantha (2026); evidence level 1]
- Creatine is naturally found in red meat and seafood, with trace amounts found in some plants. [Muacevic Alexander (2026); evidence level 3]
- About 95% of creatine is found within skeletal muscle, with the remaining 5% in the brain, testes, and heart. [Muacevic Alexander (2026); evidence level 3]

## How To Read This Evidence

Evidence level 1 generally reflects systematic reviews or meta-analyses. Level 2 includes randomized trials, guidelines, or public-health guidance. Level 3 usually reflects observational or narrative-review evidence. Level 4 is weaker or early-stage evidence. The level is a sorting aid, not a final quality grade.

## Practical Interpretation

There is at least one systematic-review style source in the current set, so it deserves more weight than single-study evidence. For creatine working memory randomized trial, the next editorial step is to add more targeted sources and separate strong findings from early or indirect evidence.

## Limits Of This First Pass

This is a small-batch MVP article. It uses the first ingested sources for this topic and should be expanded with more targeted searches, license review, and human editorial checks before being treated as a definitive review.

## References

- Marshall Samantha (2026). Creatine and Cognition in Aging: A Systematic Review of Evidence in Older Adults. DOI: 10.1093/nutrit/nuaf135. PMCID: PMC12793482. PMID: 40971619. License: https://creativecommons.org/licenses/by-nc-nd/4.0/ https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open.... https://pmc.ncbi.nlm.nih.gov/articles/PMC12793482/
- Muacevic Alexander (2026). Creatine: Clinical Implications for Orthopedic Surgeons. DOI: 10.7759/cureus.103937. PMCID: PMC13005770. PMID: 41873283. License: CC BY 4.0. https://pmc.ncbi.nlm.nih.gov/articles/PMC13005770/

## Safety Note

Health information can change, and individual risk depends on medical history, medications, pregnancy status, age, and diagnosis. Talk with a qualified clinician before changing treatment, supplement, or medication routines.